Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | C1A39_RS07795 | Genome accession | NZ_CP028896 |
| Coordinates | 1507366..1508442 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain CS5 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1492619..1565418 | 1507366..1508442 | within | 0 |
Gene organization within MGE regions
Location: 1492619..1565418
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C1A39_RS07720 (C1A39_07950) | - | 1493510..1494061 (-) | 552 | WP_002946999.1 | isochorismatase family cysteine hydrolase | - |
| C1A39_RS07725 (C1A39_07955) | codY | 1494124..1494909 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| C1A39_RS07730 (C1A39_07960) | - | 1495169..1496383 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| C1A39_RS07735 (C1A39_07965) | - | 1496738..1497190 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| C1A39_RS07740 (C1A39_07970) | - | 1497370..1497941 (+) | 572 | Protein_1478 | IS30 family transposase | - |
| C1A39_RS07745 | - | 1498013..1498186 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| C1A39_RS07750 (C1A39_07975) | - | 1498247..1498621 (-) | 375 | WP_011681547.1 | membrane protein | - |
| C1A39_RS07755 (C1A39_07980) | pflA | 1498833..1499633 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| C1A39_RS07760 | - | 1499821..1499931 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| C1A39_RS07765 (C1A39_07990) | - | 1500629..1501960 (-) | 1332 | WP_024703987.1 | hemolysin family protein | - |
| C1A39_RS07770 (C1A39_07995) | - | 1502074..1502856 (+) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
| C1A39_RS07775 (C1A39_08000) | - | 1503478..1505544 (-) | 2067 | WP_011681548.1 | sodium:proton antiporter | - |
| C1A39_RS07780 (C1A39_08005) | - | 1505553..1505795 (-) | 243 | WP_011226461.1 | hypothetical protein | - |
| C1A39_RS07785 (C1A39_08010) | - | 1505792..1506340 (-) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| C1A39_RS07790 (C1A39_08015) | - | 1506337..1507281 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| C1A39_RS07795 (C1A39_08020) | sepM | 1507366..1508442 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| C1A39_RS07800 (C1A39_08025) | coaD | 1508420..1508917 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| C1A39_RS07805 (C1A39_08030) | rsmD | 1508951..1509550 (-) | 600 | Protein_1491 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| C1A39_RS07810 (C1A39_08035) | trxB | 1509641..1510594 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| C1A39_RS07815 (C1A39_08040) | - | 1510627..1510851 (-) | 225 | WP_014621911.1 | DUF4059 family protein | - |
| C1A39_RS07820 (C1A39_08045) | - | 1511066..1511809 (-) | 744 | WP_014608652.1 | amino acid ABC transporter ATP-binding protein | - |
| C1A39_RS07825 (C1A39_08050) | - | 1511809..1512555 (-) | 747 | WP_100284797.1 | amino acid ABC transporter permease | - |
| C1A39_RS07830 (C1A39_08055) | - | 1512943..1513773 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| C1A39_RS07835 (C1A39_08060) | - | 1514233..1514466 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| C1A39_RS07840 (C1A39_08065) | dinB | 1514764..1515867 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| C1A39_RS07845 (C1A39_08070) | pflB | 1516146..1518455 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| C1A39_RS07850 (C1A39_08075) | - | 1518722..1519504 (+) | 783 | WP_011681555.1 | carbonic anhydrase family protein | - |
| C1A39_RS07855 (C1A39_08080) | - | 1519555..1520007 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| C1A39_RS07860 (C1A39_08090) | - | 1520358..1520663 (-) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| C1A39_RS10310 (C1A39_08095) | mobV | 1520688..1521196 (-) | 509 | Protein_1503 | MobV family relaxase | - |
| C1A39_RS07870 (C1A39_08100) | fetB | 1521641..1522396 (-) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| C1A39_RS07875 (C1A39_08105) | - | 1522393..1523043 (-) | 651 | WP_024703990.1 | ATP-binding cassette domain-containing protein | - |
| C1A39_RS07880 (C1A39_08110) | - | 1523246..1524202 (-) | 957 | WP_024703991.1 | serine hydrolase domain-containing protein | - |
| C1A39_RS07885 (C1A39_08115) | - | 1524202..1524957 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| C1A39_RS07890 (C1A39_08120) | - | 1525239..1525601 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| C1A39_RS07895 (C1A39_08125) | gla | 1525688..1526551 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| C1A39_RS07900 (C1A39_08130) | - | 1526672..1528939 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| C1A39_RS07905 (C1A39_08135) | - | 1529019..1529399 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| C1A39_RS07910 | - | 1529524..1529787 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| C1A39_RS07915 (C1A39_08140) | - | 1530109..1530405 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| C1A39_RS07920 (C1A39_08145) | - | 1530570..1530776 (-) | 207 | WP_011681562.1 | hypothetical protein | - |
| C1A39_RS07925 (C1A39_08150) | - | 1530807..1531499 (-) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| C1A39_RS07930 (C1A39_08155) | - | 1531690..1533260 (+) | 1571 | WP_106693466.1 | IS3-like element ISSth1b family transposase | - |
| C1A39_RS07935 (C1A39_08160) | - | 1533406..1533660 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| C1A39_RS10315 (C1A39_08165) | - | 1533911..1534312 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| C1A39_RS07940 (C1A39_08175) | - | 1535317..1535547 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| C1A39_RS07945 (C1A39_08180) | - | 1535903..1536103 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| C1A39_RS07950 (C1A39_08185) | - | 1536122..1536298 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| C1A39_RS07955 (C1A39_08190) | - | 1536554..1537285 (+) | 732 | WP_002948869.1 | LytTR family DNA-binding domain-containing protein | - |
| C1A39_RS10080 | - | 1537822..1538625 (+) | 804 | WP_224107502.1 | ATP-binding protein | - |
| C1A39_RS07965 (C1A39_08200) | - | 1538643..1538804 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| C1A39_RS07970 (C1A39_08205) | - | 1538819..1540186 (-) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| C1A39_RS07975 (C1A39_08210) | - | 1540202..1542354 (-) | 2153 | Protein_1526 | peptide cleavage/export ABC transporter | - |
| C1A39_RS07985 (C1A39_08225) | - | 1543368..1545113 (-) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| C1A39_RS07990 (C1A39_08230) | - | 1545106..1546863 (-) | 1758 | WP_024703995.1 | ABC transporter transmembrane domain-containing protein | - |
| C1A39_RS10085 (C1A39_08235) | - | 1547051..1547257 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| C1A39_RS08000 (C1A39_08240) | - | 1547462..1547989 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| C1A39_RS08005 (C1A39_08245) | rlmN | 1547991..1549160 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| C1A39_RS08010 (C1A39_08250) | - | 1549164..1549886 (-) | 723 | WP_024703996.1 | YutD family protein | - |
| C1A39_RS08015 (C1A39_08255) | - | 1549941..1551296 (-) | 1356 | WP_002948886.1 | metallophosphatase | - |
| C1A39_RS08020 (C1A39_08260) | - | 1552144..1553487 (-) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| C1A39_RS08025 (C1A39_08265) | mraY | 1553562..1554584 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| C1A39_RS08030 (C1A39_08270) | pbp2X | 1554586..1556853 (-) | 2268 | WP_011681584.1 | penicillin-binding protein PBP2X | - |
| C1A39_RS08035 (C1A39_08275) | ftsL | 1556857..1557177 (-) | 321 | WP_002948801.1 | cell division protein FtsL | - |
| C1A39_RS08040 (C1A39_08280) | rsmH | 1557180..1558130 (-) | 951 | WP_014621931.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| C1A39_RS10090 | - | 1558296..1558724 (-) | 429 | WP_011681585.1 | hypothetical protein | - |
| C1A39_RS10095 | - | 1558690..1558905 (-) | 216 | WP_011681586.1 | hypothetical protein | - |
| C1A39_RS10100 (C1A39_08290) | - | 1558902..1559288 (-) | 387 | WP_011681587.1 | hypothetical protein | - |
| C1A39_RS08050 (C1A39_08295) | - | 1559371..1559619 (+) | 249 | WP_011681588.1 | hypothetical protein | - |
| C1A39_RS08055 (C1A39_08300) | - | 1559925..1560281 (-) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| C1A39_RS08060 (C1A39_08305) | - | 1560501..1560791 (-) | 291 | WP_014621939.1 | hypothetical protein | - |
| C1A39_RS08065 (C1A39_08310) | - | 1561125..1562375 (-) | 1251 | WP_014621940.1 | glutamate-5-semialdehyde dehydrogenase | - |
| C1A39_RS08070 (C1A39_08315) | proB | 1562377..1563180 (-) | 804 | WP_014621941.1 | glutamate 5-kinase | - |
| C1A39_RS08075 (C1A39_08320) | - | 1563301..1564890 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=288307 C1A39_RS07795 WP_011681549.1 1507366..1508442(-) (sepM) [Streptococcus thermophilus strain CS5]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=288307 C1A39_RS07795 WP_011681549.1 1507366..1508442(-) (sepM) [Streptococcus thermophilus strain CS5]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |