Detailed information NTG0284621

Bioinformatically predicted

Overview

• Name: ccpA
• Type: Regulator
• Locus tag: SM12261_RS01320
• Genome accession: NZ_CP028414
• Coordinates: 253308..254318 (+)
• Length: 336 a.a.
• NCBI ID: WP_001090627.1
• Uniprot ID: I0SX71
• Organism: Streptococcus mitis NCTC 12261
• Function: regulate comCDE transcription and transformation (predicted from homology) Competence regulation

Genomic Context

Location: 248308..259318

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SM12261_RS01295 (SM12261_0254)	folP	248904..249878 (+)	975	WP_000240964.1	dihydropteroate synthase	-
SM12261_RS01300 (SM12261_0255)	-	249880..251202 (+)	1323	WP_000658435.1	bifunctional folylpolyglutamate synthase/dihydrofolate synthase	-
SM12261_RS01305 (SM12261_0256)	folE	251183..251737 (+)	555	WP_000380931.1	GTP cyclohydrolase I FolE	-
SM12261_RS01310 (SM12261_0257)	folK	251780..252592 (+)	813	WP_000372493.1	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase	-
SM12261_RS01315 (SM12261_0258)	-	252753..253070 (-)	318	WP_000886035.1	DUF960 domain-containing protein	-
SM12261_RS01320 (SM12261_0259)	ccpA	253308..254318 (+)	1011	WP_001090627.1	catabolite control protein A	Regulator
SM12261_RS01325 (SM12261_0260)	-	254372..255334 (-)	963	WP_001124765.1	asparaginase	-
SM12261_RS01330 (SM12261_0261)	-	255400..256791 (+)	1392	WP_078228369.1	Cof-type HAD-IIB family hydrolase	-
SM12261_RS01335 (SM12261_0262)	-	257007..257459 (-)	453	WP_000079148.1	universal stress protein	-
SM12261_RS01340 (SM12261_0263)	-	257621..257923 (+)	303	WP_000977176.1	hypothetical protein	-
SM12261_RS01345 (SM12261_0264)	-	258080..259294 (+)	1215	WP_000666474.1	pyridoxal phosphate-dependent aminotransferase	-

Sequence

Protein

• Length: 336 a.a.
• Molecular weight: 37169.19 Da
• Isoelectric Point: 5.3350

>NTDB_id=284621 SM12261_RS01320 WP_001090627.1 253308..254318(+) (ccpA) [Streptococcus mitis NCTC 12261]
MNTDDTVTIYDVAREAGVSMATVSRVVNGNKNVKENTRKKVLEVIDRLDYRPNAVARGLASKKTTTVGVVIPNITNGYFS
TLAKGIDDIAEMYKYNIVLANSDEDDDKEVSVVNTLFSKQVDGIIFMGYHLTEKIRSEFSRSRTPVVLAGTVDVEHQLPS
VNIDYKQATIDAVTYLAKENERIAFVSGPLVDDINGKVRLVGYKEALKKAGISYSEGLVFESKYTYEDGYALAERLISSN
ATAAVVTGDELAAGVLNGLADKGVSVPEEFEIITSDDSQISRFTRPNLTTIAQPLYDLGAISMRMLTKIMHKEELEEREV
LLPHGLTERRSTRKRK

Nucleotide

• Length: 1011 bp

>NTDB_id=284621 SM12261_RS01320 WP_001090627.1 253308..254318(+) (ccpA) [Streptococcus mitis NCTC 12261]
ATGAATACAGACGATACAGTAACGATTTATGATGTCGCCCGTGAAGCAGGAGTTTCAATGGCGACAGTTAGCCGTGTAGT
CAATGGCAATAAGAATGTAAAAGAGAATACTCGTAAAAAAGTGCTTGAGGTGATTGACCGTTTGGATTACCGTCCAAATG
CAGTGGCGCGTGGTCTTGCAAGTAAAAAGACAACCACTGTCGGTGTGGTGATACCAAATATTACCAATGGTTATTTCTCA
ACGCTTGCCAAAGGGATTGATGATATTGCTGAAATGTACAAGTATAATATCGTTCTTGCTAATAGTGATGAGGATGATGA
TAAGGAAGTTTCAGTTGTCAATACCCTGTTTTCTAAGCAAGTGGATGGTATCATCTTTATGGGGTACCACTTGACTGAAA
AAATTCGTTCAGAGTTTTCTCGTTCTCGAACACCAGTTGTTCTTGCAGGAACTGTGGATGTAGAACACCAACTTCCAAGT
GTTAATATTGACTACAAACAAGCTACGATTGATGCAGTGACCTACCTTGCTAAAGAAAATGAGCGCATTGCTTTCGTAAG
CGGTCCACTAGTGGATGATATCAATGGTAAGGTTCGTTTGGTTGGCTACAAGGAAGCCTTGAAAAAAGCAGGTATTTCTT
ATAGCGAAGGATTGGTATTTGAGTCTAAATACACTTATGAAGATGGTTATGCCTTGGCAGAACGCTTGATTTCATCAAAC
GCAACTGCAGCAGTTGTAACAGGTGATGAGCTGGCAGCAGGTGTCTTGAACGGCCTTGCTGATAAGGGTGTATCAGTACC
AGAAGAATTTGAAATCATTACTAGTGATGATTCACAAATCTCACGCTTTACCCGTCCAAACTTGACAACTATTGCCCAAC
CTCTTTATGACCTTGGGGCCATCAGTATGCGTATGTTGACCAAGATTATGCACAAGGAAGAGTTGGAAGAACGTGAAGTT
CTCTTACCTCATGGTTTGACAGAACGTCGCTCAACACGAAAACGGAAATAG

Domains

Predicted by InterproScan.

• Bacterial regulatory proteins, lacI family (LacI) (8-53)

• Periplasmic binding protein-like domain (Peripla_BP_3) (181-332)

3D structure

• AlphaFold DB: I0SX71

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccpA	Streptococcus pneumoniae D39	95.536	100	0.955
ccpA	Streptococcus gordonii str. Challis substr. CH1	89.521	99.405	0.89
ccpA	Lactococcus lactis subsp. lactis strain DGCC12653	58.006	98.512	0.571