Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   EB816_RS01170 Genome accession   NZ_CP033337
Coordinates   203113..204474 (+) Length   453 a.a.
NCBI ID   WP_023612230.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain TSPY453     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 198113..209474
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EB816_RS10105 - 199326..199469 (-) 144 WP_023612234.1 hypothetical protein -
  EB816_RS10425 - 200244..200375 (+) 132 WP_023612236.1 hypothetical protein -
  EB816_RS01165 (EB816_01165) comA 200954..203104 (+) 2151 WP_023612228.1 peptide cleavage/export ABC transporter ComA Regulator
  EB816_RS01170 (EB816_01170) comB 203113..204474 (+) 1362 WP_023612230.1 bacteriocin secretion accessory protein Regulator
  EB816_RS01175 (EB816_01175) - 204616..204789 (+) 174 WP_023612227.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  EB816_RS01180 (EB816_01180) - 204808..204975 (+) 168 WP_023612226.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  EB816_RS01190 (EB816_01190) - 205612..206961 (+) 1350 WP_011888573.1 glucose-6-phosphate isomerase -
  EB816_RS01195 (EB816_01195) - 207310..208818 (-) 1509 WP_002986134.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 453 a.a.        Molecular weight: 50761.54 Da        Isoelectric Point: 8.0810

>NTDB_id=283147 EB816_RS01170 WP_023612230.1 203113..204474(+) (comB) [Streptococcus pyogenes strain TSPY453]
MYEELLESSEFYQKRYHNFSSRIILPILGLLIFLVIFLTFMKKEVTIKSQATVEPVKVLAQIQSISNNTIKINNLQENKL
VNKYDLLIEYEISNEIIQHDSTQDQLNILKQQKEQLELLKSSIQSGSSKFPEADAFGYYKRFEDYIGQRQTITSNVKQQN
GTIASQNTASKNTQNTIGGLINDTSQKIANYEAAKSAIQSGRVVDATNPAYSIYSTYVSQSLALVKEVEKTTLMNQVVAQ
LDSQIQQYKTALSNYQIQYSGAGVQQAYNSSLDSQLDSLQSQKIAEISQELTALDQKVKELNGGFLLQQNTLKETELRAS
VAGIVHVNPEVIDSSIIPKGTIIAQIFPKLEDAKEARIETYISSRDITSLKIGDTVKFKTQDSSNKEVTLQSKITSIDSS
ATKTKEGSYFKVIAKVKLSSKQLQDLKYGSSGDLVVITGEKTYLKYYIDKFLN

Nucleotide


Download         Length: 1362 bp        

>NTDB_id=283147 EB816_RS01170 WP_023612230.1 203113..204474(+) (comB) [Streptococcus pyogenes strain TSPY453]
ATGTACGAAGAACTATTAGAAAGCTCGGAATTTTATCAGAAACGTTATCATAATTTTTCAAGTAGAATTATTTTACCAAT
ACTTGGTTTATTGATTTTTTTGGTTATCTTTTTAACGTTTATGAAAAAGGAAGTCACGATAAAAAGCCAAGCAACAGTTG
AGCCAGTAAAAGTATTAGCTCAAATTCAATCAATTAGTAATAATACAATTAAAATAAATAATCTTCAAGAAAATAAATTA
GTCAATAAATATGATTTACTTATTGAATATGAGATATCTAATGAGATAATTCAACATGATAGTACTCAAGATCAGTTAAA
TATTCTTAAACAACAAAAAGAACAATTGGAATTATTGAAATCTAGTATTCAGAGTGGAAGTAGCAAATTTCCTGAAGCAG
ATGCCTTTGGTTACTACAAGCGATTTGAAGATTATATCGGCCAACGTCAAACGATTACTAGTAATGTAAAACAACAAAAT
GGAACCATAGCATCTCAAAATACAGCATCAAAAAACACTCAAAATACAATTGGAGGTCTGATCAATGATACCTCTCAAAA
AATAGCAAATTATGAAGCAGCTAAAAGTGCAATTCAAAGTGGCCGAGTAGTAGATGCTACTAATCCAGCTTATTCTATTT
ATTCAACTTATGTGAGTCAAAGTTTAGCATTGGTTAAAGAAGTTGAAAAAACAACGTTAATGAATCAGGTAGTTGCTCAA
CTTGATTCTCAAATACAACAATATAAAACAGCATTATCAAATTATCAGATTCAGTATTCTGGAGCAGGAGTACAGCAAGC
TTATAATTCAAGTTTAGATAGTCAACTTGATTCATTACAATCGCAAAAAATAGCAGAGATAAGTCAGGAATTAACGGCTT
TAGATCAAAAAGTTAAGGAATTGAATGGTGGCTTCTTATTGCAACAAAATACTTTAAAAGAGACTGAACTTAGAGCTAGT
GTAGCAGGAATTGTTCATGTCAATCCTGAAGTGATTGATTCATCTATTATTCCTAAAGGGACAATTATTGCACAAATCTT
CCCGAAGTTAGAAGATGCGAAAGAAGCCAGAATTGAGACCTACATATCTTCTAGAGACATAACGAGCTTGAAAATTGGTG
ATACAGTTAAATTCAAGACCCAGGATTCTTCAAATAAAGAAGTTACCTTGCAATCTAAGATAACCAGTATTGACAGTAGT
GCAACTAAGACAAAAGAGGGGAGTTATTTTAAAGTTATTGCCAAAGTAAAATTATCAAGTAAACAGTTACAAGATTTGAA
ATATGGTTCATCAGGAGATTTAGTTGTGATAACCGGAGAGAAAACTTACCTAAAATATTATATTGATAAATTTTTAAATT
AG

Domains

Predicted by InterProScan.

HlyD family secretion protein ()

(317-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae R6

47.461

100

0.475
  comB Streptococcus pneumoniae Rx1

47.461

100

0.475
  comB Streptococcus pneumoniae D39

47.461

100

0.475
  comB Streptococcus mitis SK321

47.241

100

0.472
  comB Streptococcus pneumoniae TIGR4

47.241

100

0.472
  comB Streptococcus gordonii str. Challis substr. CH1

47.241

100

0.472
  comB Streptococcus mitis NCTC 12261

46.578

100

0.466

Multiple sequence alignment