Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SGO_RS10030 Genome accession   NC_009785
Coordinates   2113786..2115729 (-) Length   647 a.a.
NCBI ID   WP_012131022.1    Uniprot ID   A8AZU1
Organism   Streptococcus gordonii str. Challis substr. CH1     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2108786..2120729
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGO_RS10000 (SGO_2047) - 2110292..2110702 (+) 411 WP_012131016.1 helix-turn-helix domain-containing protein -
  SGO_RS10005 (SGO_2048) - 2110754..2111413 (-) 660 WP_041789818.1 CPBP family intramembrane glutamic endopeptidase -
  SGO_RS10010 (SGO_2049) - 2111418..2111972 (-) 555 WP_012131018.1 DNA-3-methyladenine glycosylase I -
  SGO_RS10015 (SGO_2050) ruvA 2111982..2112572 (-) 591 WP_012131019.1 Holliday junction branch migration protein RuvA Machinery gene
  SGO_RS10020 (SGO_2051) - 2112742..2113245 (+) 504 WP_012131020.1 helix-turn-helix domain-containing protein -
  SGO_RS10025 (SGO_2052) - 2113229..2113750 (+) 522 WP_012131021.1 RDD family protein -
  SGO_RS10030 (SGO_2053) hexB 2113786..2115729 (-) 1944 WP_012131022.1 DNA mismatch repair endonuclease MutL Machinery gene
  SGO_RS10035 (SGO_2054) - 2115914..2116354 (+) 441 WP_012131023.1 LytTR family DNA-binding domain-containing protein -
  SGO_RS10040 (SGO_2055) - 2116351..2116821 (+) 471 WP_012131024.1 DUF3021 domain-containing protein -
  SGO_RS10045 (SGO_2056) hexA 2116870..2119413 (-) 2544 WP_012131025.1 DNA mismatch repair protein MutS Machinery gene
  SGO_RS10050 (SGO_2057) argR 2119592..2120029 (-) 438 WP_008809983.1 arginine repressor -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 73305.43 Da        Isoelectric Point: 5.1261

>NTDB_id=27117 SGO_RS10030 WP_012131022.1 2113786..2115729(-) (hexB) [Streptococcus gordonii str. Challis substr. CH1]
MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKTIQVTDNGEGIDHEDVPLALRRHATSK
IKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATENGQHGTLLVAQGGEIEEHEPTSSPVGTKIKIEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLISDGREMTRTAGSGNLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALISQ
AIAASLKEQDLIPDALENLAKSTVKRATKPEQTSLPLKENRLYYDKERNDFFLKPQVAEQQISFEESAEPIHEATDEKAE
PQPTSVKFAERKPASYDQLDHPELNQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVKY
EYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMKLLEDAGIFLEEYGANQFILREHPIWFKEEEIEDGIYEMCDML
LLTKEVSIKKYRAELAIMMSCKRSIKANHGLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRELGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=27117 SGO_RS10030 WP_012131022.1 2113786..2115729(-) (hexB) [Streptococcus gordonii str. Challis substr. CH1]
ATGTCAAAAATTATCGAACTTCCAGAAATTCTAGCCAATCAGATTGCGGCTGGTGAGGTCATTGAGAGGCCCAGTAGCGT
GGTCAAGGAGCTAGTGGAAAATTCAATTGATGCGGGTGCTAGCCAGATTACCATCGAAATCGAGGAGGCTGGACTCAAGA
CTATCCAGGTGACAGATAATGGTGAGGGCATAGATCACGAAGATGTCCCTCTGGCCCTTCGCCGCCATGCTACCAGTAAA
ATCAAGAAACAGGCGGATCTCTTTCGGATTCGGACACTGGGTTTTCGTGGCGAGGCCATTCCTTCCATTGCTTCTGTATC
GCGTTTTACCATTGAGACTGCAACAGAAAATGGCCAGCACGGGACTTTGCTAGTTGCCCAAGGCGGTGAGATAGAAGAGC
ACGAGCCTACCAGCAGTCCAGTGGGAACGAAAATCAAGATAGAAGATCTTTTCTTCAATACTCCCGCCCGGCTCAAGTAT
ATGAAGAGCCAGCAGGCTGAGCTGTCCCATATCGTTGATGTGATTAATCGGCTCAGTCTGGCCCATCCGGAAGTAGCTTT
CACCCTTATCAGTGACGGCCGCGAAATGACACGGACTGCCGGCAGTGGCAATCTGCGTCAGGCTATTGCAGGCATCTATG
GTCTGGCAACAGCCAAGAAAATGGTGGAAATCTCTGCTTCAGATCTGGACTTTGAAGTGAGCGGCTATGTCAGTCTGCCT
GAACTGACTCGCGCGAATCGGAATTATATTACGATTCTCATTAACGGCCGCTATATCAAGAATTTCCTGCTCAATCGTGC
TATTTTGGACGGCTACGGCAGCAAGCTTATGGTAGGCCGCTTTCCACTAGCAGTCATCAATATCCAGATTGATCCCTATC
TGGCCGATGTCAATGTCCATCCGACCAAGCAAGAGGTGAGGATTTCTAAAGAACGGGAACTCATGGCCTTGATTTCACAA
GCCATTGCGGCTAGTCTCAAGGAGCAGGACCTTATCCCAGATGCTTTGGAAAATCTAGCCAAATCAACTGTTAAGCGTGC
GACTAAACCCGAACAGACCAGCCTCCCGCTGAAAGAAAATCGCCTCTACTACGATAAGGAGCGGAATGACTTCTTCCTCA
AGCCACAAGTGGCCGAGCAGCAAATATCCTTTGAAGAATCAGCGGAGCCTATTCATGAAGCGACAGACGAAAAAGCAGAA
CCGCAACCGACTTCGGTCAAATTCGCAGAGAGAAAGCCGGCTAGCTATGACCAACTGGACCATCCAGAGCTAAACCAGGC
CAGTCTGGAGCGAGCTGTGGATAAGTTGGAGCAGGAAGAGAAGTCAAGCTTCCCAGAGTTAGAATATTTCGGTCAGATGC
ATGGGACCTATCTCTTTGCTCAGGGCAAGGGCGGTCTTTACATTATTGACCAGCATGCTGCTCAAGAGCGGGTCAAGTAT
GAGTATTATCGGGAGAAGATTGGGGATGTGGACAATAGCCAGCAGCAGCTCTTAGTGCCCTATATCTTTGAATTTCCAGC
GGACGATATGTTGCGAATCAAGCAGCGGATGAAGCTGTTAGAAGATGCTGGCATCTTTTTAGAAGAGTACGGAGCTAACC
AGTTTATCCTCCGCGAGCATCCCATTTGGTTCAAGGAAGAGGAGATTGAAGACGGCATCTATGAGATGTGCGATATGCTT
CTCCTGACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAACTAGCCATTATGATGAGTTGCAAACGCTCCATCAAGGC
CAATCACGGTCTGGATGACTACTCTGCGCGTGACTTGCTCTTTCAGCTGTCCCAGTGTGACAATCCTTATAACTGCCCAC
ACGGCCGGCCGGTCTTGGTTAACTTTACCAAGTCGGATATGGAAAAAATGTTCCGTCGCATTCAGGAAAATCATACTAGC
CTACGGGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(449-590)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AZU1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.812

100

0.781

Multiple sequence alignment