Detailed information NTG0268288

Bioinformatically predicted

Overview

• Name: uvrB
• Type: Machinery gene
• Locus tag: DZN59_RS03925
• Genome accession: NZ_CP031636
• Coordinates: 773992..775983 (+)
• Length: 663 a.a.
• NCBI ID: WP_011284900.1
• Uniprot ID: Q48SZ1
• Organism: Streptococcus pyogenes strain MGAS10826
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 768992..780983

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DZN59_RS03910 (DZN59_03910)	-	769210..770589 (+)	1380	WP_002992849.1	PTS transporter subunit EIIC	-
DZN59_RS09390	-	770586..770738 (+)	153	WP_003062002.1	hypothetical protein	-
DZN59_RS03915 (DZN59_03915)	-	770886..771626 (-)	741	WP_011284902.1	amino acid ABC transporter ATP-binding protein	-
DZN59_RS03920 (DZN59_03920)	-	771626..773800 (-)	2175	WP_011284901.1	ABC transporter substrate-binding protein/permease	-
DZN59_RS03925 (DZN59_03925)	uvrB	773992..775983 (+)	1992	WP_011284900.1	excinuclease ABC subunit UvrB	Machinery gene
DZN59_RS03930 (DZN59_03930)	-	776247..776390 (+)	144	WP_002984200.1	teichoic acid D-Ala incorporation-associated protein DltX	-
DZN59_RS03935 (DZN59_03935)	dltA	776402..777940 (+)	1539	WP_011284899.1	D-alanine--poly(phosphoribitol) ligase subunit DltA	-
DZN59_RS03940 (DZN59_03940)	dltB	777937..779193 (+)	1257	WP_002994626.1	D-alanyl-lipoteichoic acid biosynthesis protein DltB	-
DZN59_RS03945 (DZN59_03945)	dltC	779211..779450 (+)	240	WP_002984216.1	D-alanine--poly(phosphoribitol) ligase subunit DltC	-
DZN59_RS03950 (DZN59_03950)	dltD	779443..780693 (+)	1251	WP_002984219.1	D-alanyl-lipoteichoic acid biosynthesis protein DltD	-

Sequence

Protein

• Length: 663 a.a.
• Molecular weight: 75678.74 Da
• Isoelectric Point: 4.6420

>NTDB_id=268288 DZN59_RS03925 WP_011284900.1 773992..775983(+) (uvrB) [Streptococcus pyogenes strain MGAS10826]
MIDKRDDKPFKLKSKYKPSGDQPQAIESLVDNIEGGEKAQILLGATGTGKTYTMSQVISKVNKPTLVIAHNKTLAGQLYG
EFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYA
DSAVSLRPGQEISRDTLLNQLVDIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRICEIESLTGKTI
GEVDHLVLFPATHFVTNDEHMEQSIAKIQAELAEQLQLFESEGKLLEAQRLRQRTEYDIEMLREMGYTSGVENYSRHMDG
RSPGEPPYTLLDFFPEDFLIMIDESHMTMGQIKGMYNGDQARKQMLVDYGFRLPSALDNRPLRREEFESHVHQIIYVSAT
PGEYEMSQTNTIIEQIIRPTGLLDPEIDVRPSMGQMDDLLGEINQRVARDERTFITTLTKKMAEDLTDYLKEMGVKVKYM
HSDIKTLERTEIIRDLRLGVFDVLIGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNVDGHVIMYADK
MTDSMQRAIDETARRREIQIAYNKAHGIVPQTIKKDIRGLISISKTSHNDISKEEMDYESMSRGERKEAINALQKQMQEA
AELLDFELAAQMRDLILELKLMD

Nucleotide

• Length: 1992 bp

>NTDB_id=268288 DZN59_RS03925 WP_011284900.1 773992..775983(+) (uvrB) [Streptococcus pyogenes strain MGAS10826]
ATGATTGATAAACGTGATGATAAACCATTTAAACTAAAATCAAAGTATAAACCGTCTGGTGATCAGCCACAAGCTATTGA
AAGCCTAGTTGATAATATTGAGGGCGGAGAAAAAGCTCAGATTCTCCTAGGTGCTACAGGAACGGGAAAAACATACACCA
TGAGCCAAGTAATTAGTAAAGTAAATAAACCTACCTTAGTGATAGCTCACAATAAAACCTTAGCAGGACAATTATATGGT
GAATTTAAAGAATTTTTTCCAGACAATGCTGTGGAATACTTTGTTTCCTATTATGATTACTACCAACCTGAAGCATATGT
CCCATCAAGCGACACCTATATCGAAAAAGATAGTTCAGTCAATGATGAAATCGATAAACTTCGCCATTCAGCCACCTCTT
CTTTACTTGAGCGTAACGATGTCATAGTGGTAGCTTCTGTATCTTGTATTTATGGACTAGGTTCGCCAAAAGAGTACGCA
GATTCAGCAGTCAGCCTACGTCCAGGTCAGGAGATATCACGTGACACTTTGCTAAATCAATTAGTAGATATTCAATTTGA
GCGTAATGATATTGATTTTCAACGCGGCTGTTTTCGTGTACGTGGCGATGTTGTTGAGGTCTTTCCAGCATCCAGGGATG
AACATGCTTTTCGGGTGGAATTTTTCGGGGATGAGATTGATCGTATATGTGAAATCGAAAGTTTAACTGGGAAAACTATT
GGAGAAGTTGACCATTTGGTTTTATTTCCAGCTACTCACTTTGTAACAAATGATGAGCATATGGAGCAATCAATAGCCAA
AATTCAAGCAGAGTTAGCAGAGCAGTTACAGTTATTTGAATCTGAAGGTAAACTACTAGAAGCACAGCGATTACGCCAAA
GAACGGAATATGATATTGAAATGTTACGTGAAATGGGCTATACTAGCGGAGTCGAAAACTATTCCCGTCATATGGATGGC
AGGTCACCAGGAGAACCTCCTTATACCTTGTTAGATTTCTTCCCAGAAGATTTTTTAATTATGATTGATGAAAGTCACAT
GACAATGGGACAAATCAAAGGCATGTATAATGGTGACCAAGCCAGAAAACAAATGCTAGTTGACTATGGTTTTCGATTGC
CATCAGCTCTTGATAATCGTCCCTTAAGACGCGAGGAATTTGAAAGTCATGTGCACCAAATTATCTATGTTTCAGCAACG
CCTGGTGAATACGAAATGTCACAGACTAATACAATTATTGAGCAAATTATTCGTCCGACTGGGCTACTTGATCCTGAAAT
TGATGTAAGGCCAAGTATGGGGCAAATGGATGATTTGTTGGGAGAAATTAACCAGCGCGTAGCGCGCGATGAACGGACGT
TCATCACAACCTTAACTAAAAAAATGGCAGAAGATTTGACTGATTATCTAAAAGAGATGGGTGTCAAGGTCAAGTATATG
CACAGTGATATTAAAACCTTAGAGCGGACAGAAATTATTCGTGATTTACGACTTGGTGTTTTTGATGTCTTGATTGGAAT
CAATCTGCTCCGTGAAGGGATTGATGTGCCAGAAGTTAGTCTTGTAGCCATTTTGGATGCTGATAAAGAGGGTTTCCTCC
GTAATGAACGCGGCTTGATTCAGACCATCGGTAGAGCAGCTCGAAACGTAGATGGTCATGTCATTATGTATGCGGACAAG
ATGACAGATTCTATGCAGCGGGCTATTGACGAAACGGCTCGTCGTCGTGAGATTCAAATAGCATATAACAAAGCGCACGG
CATCGTTCCACAAACTATAAAAAAAGACATCAGAGGCCTTATTAGTATAAGTAAAACAAGCCACAATGATATATCGAAAG
AAGAGATGGATTATGAAAGTATGTCAAGAGGAGAACGAAAAGAAGCGATCAATGCTCTGCAAAAACAAATGCAAGAGGCA
GCTGAATTACTTGATTTCGAATTGGCAGCTCAAATGCGAGACTTGATTTTAGAACTTAAATTAATGGACTAG

Domains

Predicted by InterProScan.

• Ultra-violet resistance protein B (UvrB) (556-598)

• Type III restriction enzyme, res subunit (ResIII) (17-142)

• Helicase conserved C-terminal domain (Helicase_C) (443-548)

• UvrB/uvrC motif (UVR) (627-660)

• UvrB interaction domain (UvrB_inter) (164-254)

3D structure

• AlphaFold DB: Q48SZ1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
uvrB	Streptococcus pneumoniae R6	84.917	100	0.849
uvrB	Streptococcus pneumoniae D39	84.917	100	0.849
uvrB	Streptococcus pneumoniae TIGR4	84.766	100	0.848