Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPYM_RS02510 Genome accession   NC_009332
Coordinates   497032..497673 (+) Length   213 a.a.
NCBI ID   WP_011888671.1    Uniprot ID   -
Organism   Streptococcus pyogenes str. Manfredo     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 492032..502673
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM_RS02490 (SpyM50455) - 492588..493328 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SPYM_RS02495 (SpyM50456) pknB 493325..495223 (+) 1899 WP_011888669.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SPYM_RS02500 (SpyM50457) liaF 495346..496038 (+) 693 WP_011888670.1 cell wall-active antibiotics response protein LiaF -
  SPYM_RS02505 (SpyM50458) - 496035..497039 (+) 1005 WP_002991890.1 sensor histidine kinase -
  SPYM_RS02510 (SpyM50459) vraR 497032..497673 (+) 642 WP_011888671.1 response regulator transcription factor Regulator
  SPYM_RS02515 (SpyM50460) - 497710..499110 (+) 1401 WP_011888672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  SPYM_RS02520 (SpyM50461) - 499110..499487 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  SPYM_RS02525 (SpyM50462) cysK 499505..500446 (-) 942 WP_011888673.1 cysteine synthase A -
  SPYM_RS02530 (SpyM50463) - 500574..501206 (-) 633 WP_009880468.1 YigZ family protein -
  SPYM_RS02535 (SpyM50464) comFA/cflA 501262..502587 (+) 1326 WP_011184811.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23777.52 Da        Isoelectric Point: 5.1641

>NTDB_id=26468 SPYM_RS02510 WP_011888671.1 497032..497673(+) (vraR) [Streptococcus pyogenes str. Manfredo]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVLKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=26468 SPYM_RS02510 WP_011888671.1 497032..497673(+) (vraR) [Streptococcus pyogenes str. Manfredo]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTTAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.427

96.714

0.507
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment