Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   DW289_RS09580 Genome accession   NZ_CP031321
Coordinates   1875642..1876232 (-) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1870642..1881232
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DW289_RS09565 (DW289_09565) uhpT 1871282..1872673 (-) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -
  DW289_RS09570 (DW289_09570) uhpC 1872811..1874130 (-) 1320 WP_001296914.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  DW289_RS09575 (DW289_09575) uhpB 1874140..1875642 (-) 1503 WP_001295243.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  DW289_RS09580 (DW289_09580) letA 1875642..1876232 (-) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  DW289_RS09585 (DW289_09585) ilvN 1876314..1876598 (-) 285 Protein_1752 acetolactate synthase small subunit -
  DW289_RS09590 (DW289_09590) ilvB 1876602..1878290 (-) 1689 WP_000168432.1 acetolactate synthase large subunit -
  DW289_RS09595 (DW289_09595) ivbL 1878396..1878494 (-) 99 WP_001315912.1 ilvB operon leader peptide IvbL -
  DW289_RS09615 (DW289_09615) tisB 1879059..1879148 (+) 90 WP_000060506.1 type I toxin-antitoxin system toxin TisB -
  DW289_RS25740 ysdE 1879411..1879485 (-) 75 WP_211180519.1 protein YsdE -
  DW289_RS09625 (DW289_09625) emrD 1879567..1880751 (+) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=264115 DW289_RS09580 WP_000633668.1 1875642..1876232(-) (letA) [Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=264115 DW289_RS09580 WP_000633668.1 1875642..1876232(-) (letA) [Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGTGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378

Multiple sequence alignment