Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SSA_RS11045 Genome accession   NC_009009
Coordinates   2251331..2253274 (-) Length   647 a.a.
NCBI ID   WP_011837650.1    Uniprot ID   A3CR14
Organism   Streptococcus sanguinis SK36     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2246331..2258274
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS11005 - 2246569..2246907 (-) 339 WP_002894090.1 hypothetical protein -
  SSA_RS11010 (SSA_2251) - 2247209..2248057 (+) 849 WP_011837644.1 helix-turn-helix domain-containing protein -
  SSA_RS11015 - 2248067..2248174 (-) 108 Protein_2141 DNA-3-methyladenine glycosylase I -
  SSA_RS11020 (SSA_2252) - 2248302..2248955 (-) 654 Protein_2142 CPBP family intramembrane glutamic endopeptidase -
  SSA_RS11025 (SSA_2253) - 2248960..2249514 (-) 555 WP_011837646.1 DNA-3-methyladenine glycosylase I -
  SSA_RS11030 (SSA_2254) ruvA 2249524..2250114 (-) 591 WP_011837647.1 Holliday junction branch migration protein RuvA Machinery gene
  SSA_RS11035 (SSA_2255) - 2250284..2250790 (+) 507 WP_011837648.1 helix-turn-helix domain-containing protein -
  SSA_RS11040 (SSA_2256) - 2250774..2251295 (+) 522 WP_033179235.1 RDD family protein -
  SSA_RS11045 (SSA_2257) hexB 2251331..2253274 (-) 1944 WP_011837650.1 DNA mismatch repair endonuclease MutL Machinery gene
  SSA_RS11050 (SSA_2258) - 2253479..2254789 (-) 1311 WP_011837651.1 SPFH domain-containing protein -
  SSA_RS11055 (SSA_2259) - 2254817..2255512 (-) 696 WP_011837652.1 zinc ribbon domain-containing protein -
  SSA_RS11060 (SSA_2260) hexA 2255691..2258240 (-) 2550 WP_011837653.1 DNA mismatch repair protein MutS Machinery gene

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 73224.44 Da        Isoelectric Point: 5.3170

>NTDB_id=26345 SSA_RS11045 WP_011837650.1 2251331..2253274(-) (hexB) [Streptococcus sanguinis SK36]
MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKSIQVTDNGEGIDHEDVPLALRRHATSK
IKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATEAGRHGTLLVAQGGEIEEHVPTSSPVGTKIKIEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLISDGREMTRTAGSGNLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALISQ
AIATSLKEQDLIPDALENLAKSTVKRASKPEQTSLPLKENRLYYDKKQNDFFLKPQVAEQQLSFEESAKPVHEATDEKAE
PQSTSVKFAERKPVSYDQLDHPELDQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVKY
EYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMELLEDAGIFLEEYGANQFILREHPIWFKEEEIEAGIYEMCDML
LLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHTS
LRELGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=26345 SSA_RS11045 WP_011837650.1 2251331..2253274(-) (hexB) [Streptococcus sanguinis SK36]
ATGTCAAAAATTATCGAACTTCCAGAAATTCTAGCCAATCAGATTGCGGCCGGTGAAGTCATTGAGCGGCCTAGCAGCGT
GGTCAAGGAGCTGGTGGAAAATTCAATTGATGCGGGTGCAAGCCAAATTACCATCGAAATAGAAGAAGCGGGACTCAAGA
GCATTCAGGTGACGGATAATGGCGAGGGCATAGACCACGAAGATGTCCCTCTGGCCCTTCGACGTCATGCTACCAGTAAA
ATCAAGAAACAGGCGGATCTCTTTCGGATTCGGACACTGGGTTTCCGTGGTGAGGCCATTCCTTCCATTGCTTCTGTCTC
GCGTTTCACAATTGAAACAGCGACTGAAGCTGGCCGACACGGGACTTTGCTAGTTGCCCAAGGAGGTGAGATTGAAGAGC
ATGTGCCTACTAGCAGCCCGGTGGGAACGAAAATCAAGATAGAAGATCTCTTCTTCAATACTCCAGCCCGGCTCAAGTAT
ATGAAGAGCCAGCAGGCTGAGCTGTCCCATATCGTTGATGTGATTAATCGGCTCAGTCTGGCCCATCCAGAAGTGGCTTT
CACCCTTATCAGCGACGGCCGCGAAATGACGCGGACCGCCGGCAGTGGCAATCTGCGTCAGGCTATTGCAGGCATCTATG
GTTTGGCAACAGCTAAGAAAATGGTGGAAATTTCCGCTTCAGATCTGGACTTTGAGGTGAGCGGCTATGTCAGCTTGCCT
GAGCTGACTCGCGCAAATCGGAATTATATTACGATCCTTATCAACGGCCGCTACATTAAGAATTTCCTGCTTAATCGTGC
TATTTTGGACGGCTACGGCAGCAAGCTTATGGTAGGCCGCTTCCCACTAGCGGTCATCAATATTCAGATTGACCCCTATC
TGGCAGATGTCAATGTCCATCCGACCAAGCAAGAGGTGCGGATTTCTAAAGAGCGGGAACTCATGGCCCTGATTTCGCAA
GCCATTGCGACCAGTCTCAAGGAGCAGGACCTTATTCCGGATGCTTTGGAAAATCTAGCCAAATCAACTGTTAAGCGTGC
CAGTAAGCCTGAACAGACCAGCCTTCCCCTTAAAGAAAATCGCCTCTACTACGATAAGAAGCAGAATGACTTCTTCCTCA
AGCCACAGGTGGCCGAGCAGCAGCTATCCTTTGAAGAGTCAGCAAAGCCTGTTCATGAAGCGACAGATGAAAAAGCAGAA
CCGCAATCGACTTCGGTCAAATTCGCAGAGAGAAAGCCGGTCAGCTATGACCAGCTAGACCATCCAGAGCTAGACCAGGC
CAGTCTGGAGCGGGCTGTGGATAAGTTGGAACAGGAAGAGAAGTCAAGCTTCCCAGAGTTAGAATATTTCGGCCAGATGC
ATGGTACCTATCTCTTTGCTCAGGGCAAGGGCGGTCTTTACATTATTGACCAGCATGCTGCCCAAGAGCGGGTCAAGTAT
GAGTATTATCGGGAGAAGATAGGGGATGTGGACAATAGCCAGCAGCAGCTTTTAGTGCCCTATATCTTTGAATTTCCTGC
TGACGATATGCTGCGAATCAAGCAGCGGATGGAGTTGTTAGAAGATGCTGGCATTTTTTTAGAAGAGTACGGAGCCAACC
AGTTTATCCTCCGTGAACATCCCATTTGGTTCAAGGAAGAGGAGATTGAAGCCGGCATCTATGAGATGTGTGATATGCTT
CTCTTGACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAGCTAGCCATTATGATGAGCTGCAAACGCTCCATCAAGGC
CAATCATAGTCTGGATGACTACTCTGCGCGTGACTTGCTCTTTCAGCTGTCCCAGTGTGACAATCCCTATAATTGCCCAC
ACGGTCGGCCGGTCTTGGTCAACTTTACCAAGTCAGATATGGAAAAAATGTTCCGCCGCATTCAGGAAAATCATACTAGC
CTGCGGGAATTGGGGAAATACTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-116)

MutL C terminal dimerisation domain (MutL_C)

(449-591)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A3CR14

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.727

100

0.782

Multiple sequence alignment