Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   SSA_RS11060 Genome accession   NC_009009
Coordinates   2255691..2258240 (-) Length   849 a.a.
NCBI ID   WP_011837653.1    Uniprot ID   A3CR17
Organism   Streptococcus sanguinis SK36     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2250691..2263240
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS11040 (SSA_2256) - 2250774..2251295 (+) 522 WP_033179235.1 RDD family protein -
  SSA_RS11045 (SSA_2257) hexB 2251331..2253274 (-) 1944 WP_011837650.1 DNA mismatch repair endonuclease MutL Machinery gene
  SSA_RS11050 (SSA_2258) - 2253479..2254789 (-) 1311 WP_011837651.1 SPFH domain-containing protein -
  SSA_RS11055 (SSA_2259) - 2254817..2255512 (-) 696 WP_011837652.1 zinc ribbon domain-containing protein -
  SSA_RS11060 (SSA_2260) hexA 2255691..2258240 (-) 2550 WP_011837653.1 DNA mismatch repair protein MutS Machinery gene
  SSA_RS11065 (SSA_2261) argR 2258319..2258756 (-) 438 WP_002894105.1 arginine repressor -
  SSA_RS11070 (SSA_2262) argS 2259057..2260745 (+) 1689 WP_011837654.1 arginine--tRNA ligase -
  SSA_RS11075 (SSA_2263) nrdI 2260778..2261266 (-) 489 WP_011837655.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  SSA_RS11080 (SSA_2264) - 2261329..2261847 (-) 519 WP_011837656.1 ABC transporter permease -

Sequence

Protein


Download         Length: 849 a.a.        Molecular weight: 94741.09 Da        Isoelectric Point: 4.9295

>NTDB_id=26346 SSA_RS11060 WP_011837653.1 2255691..2258240(-) (hexA) [Streptococcus sanguinis SK36]
MAVEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVNAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLV
ESGYKVAIAEQMEDPKEAKGVVKREVVQVITPGTVVDSSKPDSANNFLVALDYSDGLYGLAYMDLVTGEFQVTSLEDFAL
VCGEIRNLKAREVVLGYALPEAEEQVLAGQMNLLLSYVQTALDDVQLLGEELSPMERQAAGKLLEYVHRTQMRELSHLKK
AQHYEIKDFLQMDYATKASLDLTENARSGKKHGSLYWLMDETKTAMGGRMLRSWIQRPLIDEARISQRQNVVEVFLDHFF
ERSDLTESLKGVYDIERLASRVSFGKTNPKELLQLAATLGNVPQIKAILQGIGSPHLARLIEGLDPIPELAGLISSAISP
DAPHIITEGNIIQTGFDETLDQYRLVLREGTGWIAELEVKERANSGISNLKIDYNKKDGYYFHVTNSQLAHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIQRLQALAQTLAAVDVLQSFAAVAEQQHLVRPVFT
AERRLQIEKGRHAVVEKVMGAQSYIPNSILLDQETDIQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVPAQSASLPLFDA
IFTRIGAADDLVSGQSTFMVEMMEANRAIRQASERSLILFDELGRGTATYDGMALAQAIIEHIHHYTGAKTLFATHYHEL
TALEESLEHLENVHVATLEKDGQVTFLHKIEPGPADKSYGIHVAKIAGLPEKLLERADSILSHLESQDTGLGSELPTASR
PKQSQVAEQMSLFAEGTENPVLTELRDLDIYNMTPLEVMAAVAELKKKL

Nucleotide


Download         Length: 2550 bp        

>NTDB_id=26346 SSA_RS11060 WP_011837653.1 2255691..2258240(-) (hexA) [Streptococcus sanguinis SK36]
ATGGCAGTAGAAAAGTTATCGCCAGGCATGCAGCAGTATTTGGATATCAAAAAGGACTATCCAGATGCTTTCTTGCTCTT
TCGGATGGGGGATTTCTATGAGCTGTTTTATGATGATGCAGTCAATGCCGCCCAGATTTTAGAGATTTCCCTCACCAGCC
GCAATAAAAATGCAGAAAATCCTATTCCCATGGCCGGAGTTCCCTATCATTCGGCTCAGCAGTATATTGATGTTTTGGTT
GAGTCAGGCTATAAGGTAGCGATTGCAGAGCAGATGGAAGATCCAAAGGAAGCCAAGGGCGTTGTTAAGCGGGAGGTCGT
TCAGGTTATCACTCCGGGGACGGTGGTGGACTCCAGTAAGCCGGACTCTGCCAATAACTTTCTGGTGGCTCTGGATTACT
CAGATGGCCTCTATGGTCTGGCTTATATGGATTTGGTGACCGGTGAGTTTCAGGTGACCAGTCTAGAGGACTTTGCCTTG
GTCTGCGGGGAAATTCGCAATTTGAAGGCTAGGGAAGTGGTGCTGGGCTATGCCTTGCCAGAAGCTGAGGAGCAGGTCTT
GGCTGGGCAGATGAACCTTTTACTGTCCTATGTACAGACGGCCTTGGACGATGTCCAGCTGCTAGGCGAGGAACTGTCTC
CTATGGAGCGTCAGGCAGCGGGGAAATTGCTTGAGTATGTGCACCGGACTCAGATGAGGGAGCTCAGCCATTTAAAGAAG
GCCCAGCATTATGAAATCAAGGACTTTCTGCAAATGGACTATGCCACCAAGGCGAGTCTGGATTTGACAGAAAATGCTCG
CTCGGGTAAGAAACACGGCAGTCTTTATTGGCTGATGGACGAGACCAAGACGGCCATGGGCGGCCGTATGCTGCGCTCTT
GGATCCAGCGTCCGCTGATTGATGAAGCGCGAATTAGCCAGCGGCAGAATGTCGTCGAGGTTTTTCTGGATCATTTCTTT
GAGCGGAGTGATTTGACGGAGAGCTTAAAGGGAGTCTATGATATTGAGCGGCTGGCTAGTCGGGTGTCTTTTGGCAAGAC
CAATCCCAAGGAACTGCTGCAGTTGGCAGCTACATTGGGCAATGTGCCTCAGATTAAGGCTATCCTGCAAGGGATTGGCA
GCCCTCATCTAGCTCGTTTGATTGAAGGCTTGGATCCTATTCCAGAGTTGGCAGGCTTGATTAGCTCAGCTATTTCGCCG
GATGCACCTCATATCATCACTGAGGGCAATATCATTCAGACCGGTTTTGATGAAACCTTGGATCAGTATCGGCTTGTGCT
GAGGGAGGGGACTGGATGGATTGCGGAGCTGGAAGTCAAAGAACGTGCTAACAGTGGCATCAGCAACCTGAAGATTGATT
ATAATAAAAAAGATGGTTACTATTTCCATGTGACCAATTCTCAGTTGGCTCATGTGCCTAGTCATTTCTTCCGCAAGGCG
ACCCTGAAAAATTCTGAGCGTTTCGGAACGGAGGAGTTGGCCCGGATTGAGGGAGAGATGTTGGAGGCGCGTGAAAAATC
TGCTAATCTGGAATACGAGATTTTCATGCGGATTCGCGAGGAAGCTGGCAAATACATCCAGCGCTTGCAGGCCTTGGCAC
AAACGCTGGCAGCTGTAGATGTCCTGCAGAGTTTTGCTGCGGTGGCAGAGCAACAGCATCTAGTGCGCCCAGTCTTTACT
GCAGAGCGCCGTCTGCAGATTGAAAAAGGTCGGCATGCTGTTGTGGAAAAGGTCATGGGTGCCCAAAGCTACATTCCAAA
TAGTATTCTGCTGGACCAGGAAACGGACATCCAGCTGATTACTGGCCCTAATATGAGCGGGAAATCGACTTATATGCGCC
AGCTGGCTATTATCGTCATTATGGCACAGATGGGCTCTTATGTGCCTGCTCAGTCTGCCAGTCTGCCGCTATTCGATGCG
ATTTTCACTCGCATCGGCGCGGCGGATGATCTGGTATCTGGCCAGTCCACTTTTATGGTGGAGATGATGGAGGCCAATCG
GGCCATTCGGCAGGCCAGCGAGCGTTCGCTCATTCTCTTTGATGAGCTGGGACGTGGAACGGCTACTTATGATGGGATGG
CGCTGGCTCAGGCTATTATCGAGCATATTCATCACTATACTGGAGCCAAGACCCTCTTTGCCACCCACTATCATGAGCTG
ACAGCCTTAGAGGAAAGTTTGGAGCATTTGGAAAATGTCCATGTAGCAACCTTGGAAAAGGACGGGCAGGTGACTTTCCT
GCATAAGATTGAGCCGGGTCCGGCTGACAAGTCCTACGGGATCCATGTGGCTAAAATTGCCGGACTTCCTGAGAAATTAC
TGGAGCGGGCGGATAGCATTTTGAGTCATTTGGAGAGTCAGGATACAGGACTAGGCTCAGAGCTTCCTACTGCATCCAGA
CCGAAGCAGTCGCAAGTGGCGGAGCAGATGTCTCTTTTTGCAGAAGGAACGGAAAATCCAGTCCTGACTGAACTACGAGA
CTTGGACATCTACAATATGACTCCCCTGGAAGTCATGGCGGCGGTGGCCGAGCTCAAGAAGAAGTTGTAA

Domains

Predicted by InterProScan.

MutS domain II (MutS_II)

(126-239)

MutS domain I (MutS_I)

(8-118)

MutS domain V (MutS_V)

(599-785)

MutS family domain IV (MutS_IV)

(415-505)

MutS domain III (MutS_III)

(256-546)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A3CR17

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

77.503

100

0.775
  mutS Pseudomonas stutzeri strain ATCC 17587

38.74

100

0.391

Multiple sequence alignment