Detailed information NTG0238656

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: B2G65_RS00325
• Genome accession: NZ_CP022354
• Coordinates: 53165..54076 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain GUR
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48165..59076

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B2G65_RS00305 (B2G65_00305)	purE	48461..48952 (+)	492	WP_093974496.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B2G65_RS00310 (B2G65_00310)	purK	48939..50012 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B2G65_RS00315 (B2G65_00315)	-	50033..51373 (+)	1341	WP_002987721.1	hypothetical protein	-
B2G65_RS00320 (B2G65_00320)	purB	51742..53034 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
B2G65_RS00325 (B2G65_00325)	comR	53165..54076 (+)	912	WP_014635220.1	helix-turn-helix domain-containing protein	Regulator
B2G65_RS10090	comS	54167..54265 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
B2G65_RS00330 (B2G65_00330)	ruvB	54296..55294 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
B2G65_RS00335 (B2G65_00335)	-	55432..55869 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
B2G65_RS00340 (B2G65_00340)	-	55892..56293 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
B2G65_RS00345 (B2G65_00345)	-	56290..58065 (+)	1776	WP_002994672.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=238656 B2G65_RS00325 WP_014635220.1 53165..54076(+) (comR) [Streptococcus pyogenes strain GUR]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=238656 B2G65_RS00325 WP_014635220.1 53165..54076(+) (comR) [Streptococcus pyogenes strain GUR]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366