Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CFN12_RS10395 Genome accession   NZ_CP022290
Coordinates   2001162..2001791 (-) Length   209 a.a.
NCBI ID   WP_088607876.1    Uniprot ID   -
Organism   Staphylococcus aureus strain EDCC5458     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1996162..2006791
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CFN12_RS10365 (CFN12_10310) - 1996580..1997110 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  CFN12_RS10370 (CFN12_10315) - 1997200..1998456 (-) 1257 WP_001795438.1 aminopeptidase -
  CFN12_RS10375 (CFN12_10320) - 1998459..1998659 (-) 201 WP_000180461.1 DUF1128 family protein -
  CFN12_RS10380 (CFN12_10325) - 1998806..1999270 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  CFN12_RS10385 (CFN12_10330) - 1999277..1999552 (+) 276 WP_070002542.1 YtxH domain-containing protein -
  CFN12_RS10390 (CFN12_10335) - 1999830..2001047 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  CFN12_RS10395 (CFN12_10340) vraR 2001162..2001791 (-) 630 WP_088607876.1 two-component system response regulator VraR Regulator
  CFN12_RS10400 (CFN12_10345) vraS 2001781..2002824 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  CFN12_RS10405 (CFN12_10350) liaF 2002821..2003522 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  CFN12_RS10410 (CFN12_10355) - 2003537..2003923 (-) 387 WP_001110179.1 hypothetical protein -
  CFN12_RS10415 (CFN12_10360) map 2004140..2004898 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  CFN12_RS10425 (CFN12_10370) - 2005485..2006471 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23531.27 Da        Isoelectric Point: 5.3889

>NTDB_id=238066 CFN12_RS10395 WP_088607876.1 2001162..2001791(-) (vraR) [Staphylococcus aureus strain EDCC5458]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADGVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=238066 CFN12_RS10395 WP_088607876.1 2001162..2001791(-) (vraR) [Staphylococcus aureus strain EDCC5458]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGGAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.043

100

0.99
  degU Bacillus subtilis subsp. subtilis str. 168

34.375

100

0.368

Multiple sequence alignment