Detailed information NTG0238067

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CFN12_RS10400
• Genome accession: NZ_CP022290
• Coordinates: 2001781..2002824 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain EDCC5458
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1996781..2007824

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CFN12_RS10370 (CFN12_10315)	-	1997200..1998456 (-)	1257	WP_001795438.1	aminopeptidase	-
CFN12_RS10375 (CFN12_10320)	-	1998459..1998659 (-)	201	WP_000180461.1	DUF1128 family protein	-
CFN12_RS10380 (CFN12_10325)	-	1998806..1999270 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CFN12_RS10385 (CFN12_10330)	-	1999277..1999552 (+)	276	WP_070002542.1	YtxH domain-containing protein	-
CFN12_RS10390 (CFN12_10335)	-	1999830..2001047 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CFN12_RS10395 (CFN12_10340)	vraR	2001162..2001791 (-)	630	WP_088607876.1	two-component system response regulator VraR	Regulator
CFN12_RS10400 (CFN12_10345)	vraS	2001781..2002824 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CFN12_RS10405 (CFN12_10350)	liaF	2002821..2003522 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CFN12_RS10410 (CFN12_10355)	-	2003537..2003923 (-)	387	WP_001110179.1	hypothetical protein	-
CFN12_RS10415 (CFN12_10360)	map	2004140..2004898 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CFN12_RS10425 (CFN12_10370)	-	2005485..2006471 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
CFN12_RS10435 (CFN12_10380)	-	2006961..2007374 (-)	414	WP_001549145.1	hypothetical protein	-
CFN12_RS10440 (CFN12_10385)	-	2007403..2007513 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=238067 CFN12_RS10400 WP_001017131.1 2001781..2002824(-) (vraS) [Staphylococcus aureus strain EDCC5458]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=238067 CFN12_RS10400 WP_001017131.1 2001781..2002824(-) (vraS) [Staphylococcus aureus strain EDCC5458]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1