Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   C7A06_RS04110 Genome accession   NZ_CP027599
Coordinates   774363..775022 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 97-3250     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 769363..780022
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C7A06_RS04085 parE 769454..771346 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  C7A06_RS04090 ygiN 771394..771708 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  C7A06_RS04095 mdaB 771739..772320 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  C7A06_RS04100 ygiZ 772639..772971 (+) 333 WP_000912120.1 DUF2645 family protein -
  C7A06_RS04105 qseC 773017..774366 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  C7A06_RS04110 ciaR 774363..775022 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  C7A06_RS04115 ygiW 775174..775566 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  C7A06_RS04120 ygiV 775619..776101 (+) 483 WP_000183500.1 GyrI-like domain-containing protein -
  C7A06_RS04130 parC 776647..778905 (+) 2259 WP_001281899.1 DNA topoisomerase IV subunit A -
  C7A06_RS04135 plsC 779138..779875 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=236532 C7A06_RS04110 WP_001221502.1 774363..775022(-) (ciaR) [Escherichia coli strain 97-3250]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=236532 C7A06_RS04110 WP_001221502.1 774363..775022(-) (ciaR) [Escherichia coli strain 97-3250]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365