Detailed information NTG0235430

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SE071780_RS05390
• Genome accession: NZ_CP021972
• Coordinates: 1089392..1090129 (+)
• Length: 245 a.a.
• NCBI ID: WP_012679508.1
• Uniprot ID: C0M9Q1
• Organism: Streptococcus equi subsp. equi strain ATCC 39506
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1084392..1095129

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE071780_RS05360	-	1084849..1085753 (-)	905	Protein_1027	diacylglycerol kinase family protein	-
SE071780_RS05365 (SE071780_01122)	-	1085863..1086513 (-)	651	WP_012515586.1	hemolysin III family protein	-
SE071780_RS05370 (SE071780_01123)	-	1086497..1086952 (-)	456	WP_012515587.1	DUF1836 domain-containing protein	-
SE071780_RS05375 (SE071780_01124)	-	1087213..1087968 (+)	756	WP_042356922.1	class I SAM-dependent methyltransferase	-
SE071780_RS05380 (SE071780_01125)	-	1087996..1088334 (+)	339	WP_012679506.1	cupin domain-containing protein	-
SE071780_RS05385 (SE071780_01126)	-	1088336..1088641 (+)	306	WP_012679507.1	hypothetical protein	-
SE071780_RS05390 (SE071780_01127)	comE/blpR	1089392..1090129 (+)	738	WP_012679508.1	response regulator transcription factor	Regulator
SE071780_RS05395 (SE071780_01128)	-	1090502..1090702 (+)	201	WP_012679509.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SE071780_RS05400 (SE071780_01129)	-	1090769..1091623 (+)	855	WP_012679510.1	ABC transporter ATP-binding protein	-
SE071780_RS05405 (SE071780_01130)	-	1091629..1092672 (+)	1044	WP_230197352.1	ABC transporter permease subunit	-
SE071780_RS05415 (SE071780_01133)	-	1094068..1094415 (+)	348	WP_042356926.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28892.31 Da
• Isoelectric Point: 7.8796

>NTDB_id=235430 SE071780_RS05390 WP_012679508.1 1089392..1090129(+) (comE/blpR) [Streptococcus equi subsp. equi strain ATCC 39506]
MNIFILEDDLGQQFRLEMKIQEILDKHHWTCDRFEVYGKPYQLLANVTERGRHQLFFLDIQIRNDEKKGLAVAREIRKRD
PYALIVFVTTHSELMPVSFRYQVSALDFIDKELSMKHFSDRIERAIIYAYEEQENVTSEGLFIFATAKAQVQVPFSSLLF
IETSSTPHKLILHSQNERIEFYGFLSEVLKQDSRLVQCHRSYVINPYNVSFLDRDKRLLYFKNGQSCMVSRLKMKALEAS
IKALH

Nucleotide

• Length: 738 bp

>NTDB_id=235430 SE071780_RS05390 WP_012679508.1 1089392..1090129(+) (comE/blpR) [Streptococcus equi subsp. equi strain ATCC 39506]
ATGAATATTTTTATTCTCGAAGATGATCTAGGCCAACAGTTTAGGCTTGAGATGAAGATTCAAGAGATATTGGATAAGCA
TCACTGGACTTGTGATCGTTTTGAAGTTTATGGAAAGCCCTACCAGCTTCTGGCAAATGTTACAGAGAGAGGCAGGCATC
AGCTTTTCTTTCTCGATATTCAAATTCGAAATGATGAGAAAAAGGGCTTAGCTGTTGCTCGTGAGATCAGAAAGCGTGAC
CCTTATGCCCTCATTGTTTTTGTCACCACACATTCTGAGCTTATGCCAGTTTCTTTTCGTTATCAGGTGTCTGCTCTAGA
TTTTATCGATAAGGAATTGTCAATGAAACATTTCTCAGATAGGATTGAAAGAGCCATTATATATGCTTATGAAGAGCAAG
AAAATGTAACCTCAGAGGGCTTATTTATTTTTGCAACGGCTAAGGCTCAGGTGCAGGTTCCTTTTTCAAGCCTATTGTTC
ATTGAGACCTCTAGTACTCCTCACAAGTTGATTTTGCATTCTCAAAACGAGCGAATAGAATTTTATGGCTTTCTTTCAGA
GGTTCTTAAGCAAGATTCCAGACTAGTCCAATGTCATCGTTCTTATGTTATCAATCCTTACAATGTTTCGTTTCTTGATC
GTGATAAGCGTTTACTCTATTTCAAGAATGGGCAGTCTTGCATGGTTTCAAGACTAAAAATGAAAGCACTTGAGGCGTCT
ATTAAGGCTTTGCATTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-240)

• Response regulator receiver domain (Response_reg) (18-122)

3D structure

• AlphaFold DB: C0M9Q1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.132	98.776	0.535
comE/comE1	Streptococcus equinus JB1	45.455	98.776	0.449
comE/comE2	Streptococcus equinus JB1	37.295	99.592	0.371