Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   C6W69_RS11315 Genome accession   NZ_CP027440
Coordinates   2168486..2169145 (+) Length   219 a.a.
NCBI ID   WP_001221478.1    Uniprot ID   B7UIT0
Organism   Escherichia coli strain 2012C-4502     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2163486..2174145
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C6W69_RS11300 ygiS 2165691..2167298 (-) 1608 WP_001562115.1 ABC transporter substrate-binding protein -
  C6W69_RS11305 ygiV 2167407..2167889 (-) 483 WP_000183493.1 GyrI-like domain-containing protein -
  C6W69_RS11310 ygiW 2167942..2168334 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  C6W69_RS11315 ciaR 2168486..2169145 (+) 660 WP_001221478.1 quorum sensing response regulator transcription factor QseB Regulator
  C6W69_RS11320 qseC 2169142..2170491 (+) 1350 WP_106905237.1 quorum sensing histidine kinase QseC -
  C6W69_RS11325 ygiZ 2170537..2170869 (-) 333 WP_000914696.1 DUF2645 family protein -
  C6W69_RS26955 - 2170876..2171586 (-) 711 WP_000834024.1 hypothetical protein -
  C6W69_RS26960 - 2171589..2172068 (-) 480 WP_000065329.1 Hcp family type VI secretion system effector -
  C6W69_RS11335 mdaB 2172318..2172899 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  C6W69_RS11340 ygiN 2172930..2173244 (+) 315 WP_000633738.1 putative quinol monooxygenase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24701.65 Da        Isoelectric Point: 6.9850

>NTDB_id=233933 C6W69_RS11315 WP_001221478.1 2168486..2169145(+) (ciaR) [Escherichia coli strain 2012C-4502]
MRILLIEDDMLIGDGIKTGLSKMGFSIDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=233933 C6W69_RS11315 WP_001221478.1 2168486..2169145(+) (ciaR) [Escherichia coli strain 2012C-4502]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCAT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7UIT0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365