Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   C6N23_RS07525 Genome accession   NZ_CP027342
Coordinates   1472613..1473272 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 2014C-4587     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1467613..1478272
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C6N23_RS07500 parE 1467704..1469596 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  C6N23_RS07505 ygiN 1469644..1469958 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  C6N23_RS07510 mdaB 1469989..1470570 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  C6N23_RS07515 ygiZ 1470889..1471221 (+) 333 WP_000912120.1 DUF2645 family protein -
  C6N23_RS07520 qseC 1471267..1472616 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  C6N23_RS07525 ciaR 1472613..1473272 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  C6N23_RS07530 ygiW 1473424..1473816 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  C6N23_RS07535 ygiV 1473869..1474351 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  C6N23_RS07545 parC 1474897..1477155 (+) 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
  C6N23_RS07550 plsC 1477388..1478125 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=232454 C6N23_RS07525 WP_001221502.1 1472613..1473272(-) (ciaR) [Escherichia coli strain 2014C-4587]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=232454 C6N23_RS07525 WP_001221502.1 1472613..1473272(-) (ciaR) [Escherichia coli strain 2014C-4587]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365