Detailed information NTG0232104

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: CCX85_RS02305
• Genome accession: NZ_CP021640
• Coordinates: 428290..429642 (+)
• Length: 450 a.a.
• NCBI ID: WP_002985643.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain JS12
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 423290..434642

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CCX85_RS02280 (CCX85_02290)	-	423439..423588 (+)	150	WP_002994198.1	hypothetical protein	-
CCX85_RS02285 (CCX85_02295)	-	423983..425131 (+)	1149	WP_014635346.1	acetyl-CoA C-acyltransferase	-
CCX85_RS02290 (CCX85_02300)	-	425088..426335 (+)	1248	WP_002995606.1	AMP-binding protein	-
CCX85_RS02295 (CCX85_02305)	-	426391..427425 (+)	1035	WP_011284595.1	DUF3114 domain-containing protein	-
CCX85_RS02300 (CCX85_02310)	vicR	427587..428297 (+)	711	WP_002985645.1	response regulator YycF	Regulator
CCX85_RS02305 (CCX85_02315)	vicK	428290..429642 (+)	1353	WP_002985643.1	cell wall metabolism sensor histidine kinase VicK	Regulator
CCX85_RS02310 (CCX85_02320)	vicX	429646..430455 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
CCX85_RS02315 (CCX85_02325)	rnc	430898..431590 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51439.91 Da
• Isoelectric Point: 5.5556

>NTDB_id=232104 CCX85_RS02305 WP_002985643.1 428290..429642(+) (vicK) [Streptococcus pyogenes strain JS12]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRYLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=232104 CCX85_RS02305 WP_002985643.1 428290..429642(+) (vicK) [Streptococcus pyogenes strain JS12]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGATACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAAACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• PAS fold (PAS) (95-162)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.529	94.444	0.638