Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CSC11_RS19825 Genome accession   NZ_CP027126
Coordinates   3781277..3781936 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain AR_0374     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3776277..3786936
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CSC11_RS19800 (CSC11_3716) parE 3776368..3778260 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CSC11_RS19805 (CSC11_3717) ygiN 3778308..3778622 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CSC11_RS19810 (CSC11_3718) mdaB 3778653..3779234 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CSC11_RS19815 ygiZ 3779553..3779885 (+) 333 WP_000912120.1 DUF2645 family protein -
  CSC11_RS19820 (CSC11_3720) qseC 3779931..3781280 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  CSC11_RS19825 (CSC11_3721) ciaR 3781277..3781936 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  CSC11_RS19830 (CSC11_3722) ygiW 3782088..3782480 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CSC11_RS19835 (CSC11_3723) ygiV 3782533..3783015 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  CSC11_RS19845 (CSC11_3724) parC 3783561..3785819 (+) 2259 WP_024249834.1 DNA topoisomerase IV subunit A -
  CSC11_RS19850 (CSC11_3725) plsC 3786053..3786790 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=230374 CSC11_RS19825 WP_001221502.1 3781277..3781936(-) (ciaR) [Escherichia coli strain AR_0374]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=230374 CSC11_RS19825 WP_001221502.1 3781277..3781936(-) (ciaR) [Escherichia coli strain AR_0374]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365