Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   C4962_RS00385 Genome accession   NZ_CP026929
Coordinates   73138..73728 (+) Length   196 a.a.
NCBI ID   WP_000633668.1    Uniprot ID   P0AGA7
Organism   Escherichia coli strain CFS3246     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 68138..78728
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4962_RS00355 (C4962_00365) yidF 68253..68750 (+) 498 WP_000148061.1 radical SAM protein -
  C4962_RS00360 (C4962_00370) emrD 68758..69942 (-) 1185 WP_000828746.1 multidrug efflux MFS transporter EmrD -
  C4962_RS24285 ysdE 70024..70098 (+) 75 WP_211180519.1 protein YsdE -
  C4962_RS00365 (C4962_00380) tisB 70222..70311 (-) 90 WP_001054909.1 type I toxin-antitoxin system toxin TisB -
  C4962_RS00370 (C4962_00400) ivbL 70876..70974 (+) 99 WP_001300753.1 ilvB operon leader peptide IvbL -
  C4962_RS00375 (C4962_00405) ilvB 71080..72768 (+) 1689 WP_000168475.1 acetolactate synthase large subunit -
  C4962_RS00380 (C4962_00410) ilvN 72772..73062 (+) 291 WP_001181706.1 acetolactate synthase small subunit -
  C4962_RS00385 (C4962_00415) letA 73138..73728 (+) 591 WP_000633668.1 transcriptional regulator UhpA Regulator
  C4962_RS00390 (C4962_00420) uhpB 73728..75230 (+) 1503 WP_001295243.1 signal transduction histidine-protein kinase/phosphatase UhpB -
  C4962_RS00395 (C4962_00425) uhpC 75240..76559 (+) 1320 WP_000936566.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  C4962_RS00400 (C4962_00430) uhpT 76697..78088 (+) 1392 WP_000879194.1 hexose-6-phosphate:phosphate antiporter -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 20889.30 Da        Isoelectric Point: 5.9982

>NTDB_id=228800 C4962_RS00385 WP_000633668.1 73138..73728(+) (letA) [Escherichia coli strain CFS3246]
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLMEKLGVSNDVELARRMFDGW

Nucleotide


Download         Length: 591 bp        

>NTDB_id=228800 C4962_RS00385 WP_000633668.1 73138..73728(+) (letA) [Escherichia coli strain CFS3246]
ATGATCACCGTTGCCCTTATAGACGATCACCTCATCGTCCGCTCCGGCTTTGCGCAGCTGCTGGGGCTGGAACCTGATTT
GCAGGTAGTTGCCGAGTTTGGTTCGGGGCGCGAGGCGCTGGCGGGGCTGCCGGGGCGCGGTGTGCAGGTGTGTATTTGCG
ATATCTCCATGCCCGATATCTCCGGTCTGGAGCTGCTAAGCCAGCTGCCGAAAGGTATGGCGACGATTATGCTCTCCGTT
CACGACAGTCCTGCGCTGGTTGAGCAGGCGCTTAACGCGGGGGCACGCGGCTTTCTTTCCAAACGCTGTAGCCCGGATGA
ACTCATTGCTGCGGTGCATACGGTTGCCACGGGCGGCTGTTATCTGACGCCGGATATTGCCATTAAACTGGCATCCGGTC
GTCAGGACCCGCTAACCAAACGTGAACGCCAGGTGGCGGAAAAACTGGCGCAAGGAATGGCGGTGAAAGAGATTGCCGCC
GAACTGGGCTTGTCACCGAAAACGGTACACGTCCATCGCGCCAATCTGATGGAAAAACTGGGCGTCAGTAACGACGTAGA
GCTGGCGCGCCGCATGTTTGATGGCTGGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(136-191)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0AGA7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

38.5

100

0.393
  letA Legionella pneumophila strain ERS1305867

38.5

100

0.393
  degU Bacillus subtilis subsp. subtilis str. 168

33.184

100

0.378

Multiple sequence alignment