Detailed information NTG0022817

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: SPS_RS07670
• Genome accession: NC_004606
• Coordinates: 1481256..1482611 (-)
• Length: 451 a.a.
• NCBI ID: WP_011106858.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes SSI-1
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1476256..1487611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPS_RS07660 (SPs1478)	rnc	1479308..1480000 (-)	693	WP_002990670.1	ribonuclease III	-
SPS_RS07665 (SPs1479)	vicX	1480443..1481252 (-)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
SPS_RS07670 (SPs1480)	vicK	1481256..1482611 (-)	1356	WP_011106858.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPS_RS07675 (SPs1481)	vicR	1482604..1483314 (-)	711	WP_002985645.1	response regulator YycF	Regulator
SPS_RS07680 (SPs1482)	-	1483476..1484471 (-)	996	WP_011054269.1	DUF3114 domain-containing protein	-
SPS_RS07685 (SPs1483)	-	1484567..1485814 (-)	1248	WP_011054268.1	AMP-binding protein	-
SPS_RS07690 (SPs1484)	-	1485771..1486919 (-)	1149	WP_011054267.1	acetyl-CoA C-acyltransferase	-
SPS_RS07695	-	1487314..1487463 (-)	150	WP_002994198.1	hypothetical protein	-

Sequence

Protein

• Length: 451 a.a.
• Molecular weight: 51519.95 Da
• Isoelectric Point: 5.4026

>NTDB_id=22817 SPS_RS07670 WP_011106858.1 1481256..1482611(-) (vicK) [Streptococcus pyogenes SSI-1]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1356 bp

>NTDB_id=22817 SPS_RS07670 WP_011106858.1 1481256..1482611(-) (vicK) [Streptococcus pyogenes SSI-1]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACTTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGG
ATCGACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-437)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.771	92.018	0.67
micB	Streptococcus pneumoniae Cp1015	67.606	94.457	0.639