Detailed information NTG0022589

Bioinformatically predicted

Overview

• Name: agrA
• Type: Regulator
• Locus tag: SE_RS07970
• Genome accession: NC_004461
• Coordinates: 1691865..1692581 (+)
• Length: 238 a.a.
• NCBI ID: WP_001829999.1
• Uniprot ID: C0LF82
• Organism: Staphylococcus epidermidis ATCC 12228
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1686865..1697581

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE_RS07945 (SE1633)	-	1688264..1689049 (+)	786	WP_002469371.1	carbon-nitrogen family hydrolase	-
SE_RS07950 (SE1634)	hld	1689430..1689507 (-)	78	WP_002494082.1	delta-hemolysin	-
SE_RS07955 (SE1635)	-	1689824..1690408 (+)	585	WP_001830005.1	accessory gene regulator AgrB	-
SE_RS07960 (SE1636)	agrD	1690392..1690532 (+)	141	WP_001830021.1	cyclic lactone autoinducer peptide AgrD	-
SE_RS07965 (SE1637)	agrC	1690559..1691848 (+)	1290	WP_010959211.1	quorum-sensing sensor histidine kinase AgrC	-
SE_RS07970 (SE1638)	agrA	1691865..1692581 (+)	717	WP_001829999.1	quorum-sensing response regulator AgrA	Regulator
SE_RS07975 (SE1639)	-	1692649..1693608 (-)	960	WP_002485130.1	carbohydrate kinase family protein	-
SE_RS07980 (SE1640)	-	1693615..1695087 (-)	1473	WP_001830011.1	sucrose-6-phosphate hydrolase	-
SE_RS07985	-	1695347..1696299 (-)	953	Protein_1552	LacI family DNA-binding transcriptional regulator	-

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27936.97 Da
• Isoelectric Point: 5.6250

>NTDB_id=22589 SE_RS07970 WP_001829999.1 1691865..1692581(+) (agrA) [Staphylococcus epidermidis ATCC 12228]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide

• Length: 717 bp

>NTDB_id=22589 SE_RS07970 WP_001829999.1 1691865..1692581(+) (agrA) [Staphylococcus epidermidis ATCC 12228]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCTTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAGCTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAAGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGATATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATTGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTAATAAACAGGCATAATATTGAATCTATTG
ACTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-237)

• Response regulator receiver domain (Response_reg) (3-120)

3D structure

• AlphaFold DB: C0LF82

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
agrA	Staphylococcus aureus N315	87.815	100	0.878
comE/comE2	Streptococcus gordonii strain NCTC7865	35.178	100	0.374
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	35.178	100	0.374