Detailed information NTG0225475

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B7473_RS11640
• Genome accession: NZ_CP020713
• Coordinates: 2250735..2251778 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain K17
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2245735..2256778

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B7473_RS11610 (B7473_11620)	-	2246157..2247413 (-)	1257	WP_001789555.1	aminopeptidase	-
B7473_RS11615 (B7473_11625)	-	2247416..2247616 (-)	201	WP_000180460.1	DUF1128 family protein	-
B7473_RS11620 (B7473_11630)	-	2247763..2248227 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
B7473_RS11625 (B7473_11635)	-	2248234..2248509 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
B7473_RS11630 (B7473_11640)	-	2248787..2250004 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
B7473_RS11635 (B7473_11645)	vraR	2250116..2250745 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
B7473_RS11640 (B7473_11650)	vraS	2250735..2251778 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
B7473_RS11645 (B7473_11655)	liaF	2251775..2252476 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
B7473_RS11650 (B7473_11660)	-	2252491..2252877 (-)	387	WP_101766693.1	hypothetical protein	-
B7473_RS11655 (B7473_11665)	map	2253094..2253852 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
B7473_RS11660 (B7473_11675)	-	2254381..2255367 (+)	987	WP_000999713.1	FUSC family protein	-
B7473_RS11665 (B7473_11685)	-	2255739..2256152 (-)	414	WP_001670387.1	hypothetical protein	-
B7473_RS11670 (B7473_11690)	-	2256181..2256291 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=225475 B7473_RS11640 WP_001017131.1 2250735..2251778(-) (vraS) [Staphylococcus aureus strain K17]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=225475 B7473_RS11640 WP_001017131.1 2250735..2251778(-) (vraS) [Staphylococcus aureus strain K17]
ATGAACCACTATATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1