Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   BS11774_RS13020 Genome accession   NZ_CP026010
Coordinates   2462302..2463651 (-) Length   449 a.a.
NCBI ID   WP_128474261.1    Uniprot ID   -
Organism   Bacillus subtilis strain ATCC 11774     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2457302..2468651
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BS11774_RS13005 (BS11774_12940) mhqA 2457484..2458434 (+) 951 WP_014476561.1 ring-cleaving dioxygenase -
  BS11774_RS22230 - 2458543..2458638 (+) 96 Protein_2481 hypothetical protein -
  BS11774_RS13010 (BS11774_12945) ykcB 2458651..2460801 (+) 2151 WP_029317681.1 glycosyltransferase family 39 protein -
  BS11774_RS13015 (BS11774_12950) gtcC 2460813..2461784 (+) 972 WP_029317682.1 glycosyltransferase family 2 protein -
  BS11774_RS13020 (BS11774_12955) htrA 2462302..2463651 (-) 1350 WP_128474261.1 serine protease HtrA Regulator
  BS11774_RS13025 (BS11774_12960) proG 2463820..2464638 (+) 819 WP_029317683.1 pyrroline-5-carboxylate reductase ProG -
  BS11774_RS13030 (BS11774_12965) dppA 2464767..2465591 (+) 825 WP_033884945.1 D-aminopeptidase DppA -
  BS11774_RS13035 (BS11774_12970) dppB 2465608..2466534 (+) 927 WP_003245446.1 dipeptide ABC transporter permease DppB -
  BS11774_RS13040 (BS11774_12975) dppC 2466540..2467502 (+) 963 WP_014476568.1 dipeptide ABC transporter permease DppC -
  BS11774_RS13045 (BS11774_12980) dppD 2467507..2468514 (+) 1008 WP_128473847.1 dipeptide ABC transporter ATP-binding subunit DppD -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 47744.87 Da        Isoelectric Point: 4.5990

>NTDB_id=221676 BS11774_RS13020 WP_128474261.1 2462302..2463651(-) (htrA) [Bacillus subtilis strain ATCC 11774]
MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRGFGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAK
QSSSQQQTQSVTATSTSSESKKSSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG
SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDDHVTKVANFGDSSDLRTGETVIA
IGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSINVIQTDAAINPGNSGGPLLNTDSKIVGINSMKISEDDVEGIGFA
IPSNDVKPIAEELLSKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKAEDIIIGLK
GKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=221676 BS11774_RS13020 WP_128474261.1 2462302..2463651(-) (htrA) [Bacillus subtilis strain ATCC 11774]
ATGGATAACTATCGTGATGAAAACAGAACGAAAGGTAATGAGAATGAGGTCTTTTTAACGAAAGAGAACGATCAGAGCGC
CTCCTACTCGGCCCGCAATGTCATTCATGATCAGGAGAAGAAAAAACGAGGATTCGGATGGTTCAGACCGTTGCTTGGCG
GAGTGATCGGCGGCAGTCTTGCTCTTGGCATTTACACGTTTACACCGCTTGGTGACCATGATTCTCAGGACACTGCAAAA
CAATCATCCAGCCAGCAGCAAACGCAATCTGTTACAGCAACAAGCACCTCCTCTGAATCTAAAAAAAGCTCAAGCAGCTC
ATCTGCATTCAAGAGCGAGGACTCTTCTAAAATCTCAGATATGGTAGAAGACCTTTCACCAGCGATTGTCGGTATTACAA
ATCTTCAGGCACAATCAAACAGCTCTTTGTTCGGCTCTAGTTCTTCTGATTCCAGCGAAGATACAGAAAGCGGTTCAGGG
TCAGGTGTCATTTTCAAAAAAGAGAATGGCAAGGCTTATATCATTACAAATAACCACGTCGTAGAAGGGGCATCATCACT
GAAGGTATCTTTATATGACGGCACTGAGGTTACTGCAAAGCTGGTAGGCAGTGACTCGTTAACTGATTTAGCCGTCCTCC
AAATCAGTGATGACCACGTCACAAAAGTGGCAAACTTCGGTGATTCATCTGATCTTAGAACAGGCGAGACCGTTATTGCG
ATTGGGGATCCGCTTGGAAAAGACCTGTCCCGCACAGTAACACAAGGAATTGTAAGCGGCGTGGACAGAACGGTTTCAAT
GTCTACATCAGCCGGCGAAACGAGCATTAACGTCATTCAGACAGACGCAGCAATTAATCCAGGTAACAGCGGCGGTCCTT
TGTTAAATACAGACAGCAAAATCGTCGGCATTAACAGTATGAAAATCAGTGAAGATGATGTTGAGGGTATCGGATTTGCC
ATTCCAAGCAATGACGTAAAACCGATTGCTGAAGAATTACTGTCTAAAGGACAAATTGAACGTCCATATATCGGTGTCAG
CATGCTTGATCTAGAACAAGTGCCGCAAAATTACCAAGAAGGCACACTCGGCCTGTTCGGCAGCCAGCTGAATAAAGGTG
TTTACATCCGTGAGGTCGCTTCAGGCTCTCCTGCTGAAAAGGCCGGATTAAAAGCGGAGGATATTATCATCGGCCTAAAA
GGTAAAGAAATTGATACAGGCAGTGAATTGCGCAATATCTTATATAAAGACGCAAAGATCGGTGATACCGTTGAAGTGAA
AATTCTCCGAAACGGCAAAGAAATGACGAAAAAAATTAAACTGGATCAAAAAGAAGAGAAAACTTCGTAA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(342-441)

Peptidase family M50 (Peptidase_M50)

(364-448)

Trypsin-like peptidase domain (Trypsin_2)

(160-304)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

40.796

89.532

0.365
  htrA Streptococcus pneumoniae D39

40.796

89.532

0.365
  htrA Streptococcus pneumoniae R6

40.796

89.532

0.365
  htrA Streptococcus pneumoniae TIGR4

40.796

89.532

0.365
  htrA Streptococcus mitis NCTC 12261

39.32

91.759

0.361