Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CXV93_RS18245 Genome accession   NZ_CP025856
Coordinates   3703139..3703798 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 504838     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3698139..3708798
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXV93_RS18220 parE 3698230..3700122 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CXV93_RS18225 ygiN 3700170..3700484 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CXV93_RS18230 mdaB 3700515..3701096 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CXV93_RS18235 ygiZ 3701415..3701747 (+) 333 WP_024168840.1 DUF2645 family protein -
  CXV93_RS18240 qseC 3701793..3703142 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  CXV93_RS18245 ciaR 3703139..3703798 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  CXV93_RS18250 ygiW 3703950..3704342 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CXV93_RS18255 ygiV 3704395..3704877 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  CXV93_RS18260 parC 3705423..3707681 (+) 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
  CXV93_RS18265 plsC 3707914..3708651 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=220367 CXV93_RS18245 WP_001221502.1 3703139..3703798(-) (ciaR) [Escherichia coli strain 504838]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=220367 CXV93_RS18245 WP_001221502.1 3703139..3703798(-) (ciaR) [Escherichia coli strain 504838]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365