Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CXX15_RS04900 Genome accession   NZ_CP025847
Coordinates   1017055..1017714 (+) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 602354     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1012055..1022714
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXX15_RS04880 plsC 1012202..1012939 (-) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -
  CXX15_RS04885 parC 1013172..1015430 (-) 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
  CXX15_RS04890 ygiV 1015976..1016458 (-) 483 WP_000183494.1 GyrI-like domain-containing protein -
  CXX15_RS04895 ygiW 1016511..1016903 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CXX15_RS04900 ciaR 1017055..1017714 (+) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  CXX15_RS04905 qseC 1017711..1019060 (+) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  CXX15_RS04910 ygiZ 1019106..1019438 (-) 333 WP_000912120.1 DUF2645 family protein -
  CXX15_RS04915 mdaB 1019757..1020338 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CXX15_RS04920 ygiN 1020369..1020683 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  CXX15_RS04925 parE 1020731..1022623 (-) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=220087 CXX15_RS04900 WP_001221502.1 1017055..1017714(+) (ciaR) [Escherichia coli strain 602354]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=220087 CXX15_RS04900 WP_001221502.1 1017055..1017714(+) (ciaR) [Escherichia coli strain 602354]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment