Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CXX37_RS19215 Genome accession   NZ_CP025842
Coordinates   3821157..3821816 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain 720632     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3816157..3826816
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXX37_RS19190 parE 3816248..3818140 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CXX37_RS19195 ygiN 3818188..3818502 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CXX37_RS19200 mdaB 3818533..3819114 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CXX37_RS19205 ygiZ 3819433..3819765 (+) 333 WP_000917684.1 DUF2645 family protein -
  CXX37_RS19210 qseC 3819811..3821160 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  CXX37_RS19215 ciaR 3821157..3821816 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  CXX37_RS19220 ygiW 3821968..3822360 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CXX37_RS19225 ygiV 3822413..3822895 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  CXX37_RS19230 mqsR 3823100..3823396 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  CXX37_RS19235 mqsA 3823398..3823793 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  CXX37_RS19240 ygiS 3823926..3825533 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=220050 CXX37_RS19215 WP_001221493.1 3821157..3821816(-) (ciaR) [Escherichia coli strain 720632]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=220050 CXX37_RS19215 WP_001221493.1 3821157..3821816(-) (ciaR) [Escherichia coli strain 720632]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment