Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CXX41_RS12415 Genome accession   NZ_CP025840
Coordinates   2520035..2520694 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain 214-4     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2515035..2525694
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CXX41_RS12390 parE 2515126..2517018 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  CXX41_RS12395 ygiN 2517066..2517380 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CXX41_RS12400 mdaB 2517411..2517992 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CXX41_RS12405 ygiZ 2518311..2518643 (+) 333 WP_000917684.1 DUF2645 family protein -
  CXX41_RS12410 qseC 2518689..2520038 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  CXX41_RS12415 ciaR 2520035..2520694 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  CXX41_RS12420 ygiW 2520846..2521238 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CXX41_RS12425 ygiV 2521291..2521773 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  CXX41_RS12430 mqsR 2521978..2522274 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  CXX41_RS12435 mqsA 2522276..2522671 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  CXX41_RS12440 ygiS 2522804..2524411 (+) 1608 WP_001295629.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=219948 CXX41_RS12415 WP_001221493.1 2520035..2520694(-) (ciaR) [Escherichia coli strain 214-4]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=219948 CXX41_RS12415 WP_001221493.1 2520035..2520694(-) (ciaR) [Escherichia coli strain 214-4]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365