Detailed information NTG0217946

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: CXP32_RS10120
• Genome accession: NZ_CP025256
• Coordinates: 1900572..1901471 (-)
• Length: 299 a.a.
• NCBI ID: WP_000904858.1
• Uniprot ID: A0A0H2URY1
• Organism: Streptococcus pneumoniae strain Xen35
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1895572..1906471

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXP32_RS10100 (CXP32_10100)	rsmA	1896326..1897198 (-)	873	WP_001216856.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
CXP32_RS10105 (CXP32_10105)	-	1897329..1897637 (-)	309	WP_000333257.1	hypothetical protein	-
CXP32_RS10110 (CXP32_10110)	-	1897630..1898271 (-)	642	WP_000565531.1	ABC transporter ATP-binding protein	-
CXP32_RS10115 (CXP32_10115)	-	1898273..1900303 (-)	2031	WP_000825267.1	bacteriocin-associated integral membrane family protein	-
CXP32_RS10120 (CXP32_10120)	comR	1900572..1901471 (-)	900	WP_000904858.1	helix-turn-helix transcriptional regulator	Regulator
CXP32_RS10125 (CXP32_10125)	rnmV	1901543..1902103 (-)	561	WP_000660004.1	ribonuclease M5	-
CXP32_RS10130 (CXP32_10130)	-	1902103..1902876 (-)	774	WP_000575607.1	TatD family hydrolase	-
CXP32_RS10140 (CXP32_10140)	-	1903181..1904074 (-)	894	WP_000226469.1	DUF1542 domain-containing protein	-
CXP32_RS10145 (CXP32_10145)	rpmH	1904358..1904492 (-)	135	WP_000831905.1	50S ribosomal protein L34	-
CXP32_RS10150 (CXP32_10150)	-	1904637..1905851 (-)	1215	WP_000666479.1	pyridoxal phosphate-dependent aminotransferase	-
CXP32_RS10155 (CXP32_10155)	-	1906007..1906301 (-)	295	Protein_1890	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35409.11 Da
• Isoelectric Point: 4.7119

>NTDB_id=217946 CXP32_RS10120 WP_000904858.1 1900572..1901471(-) (comR) [Streptococcus pneumoniae strain Xen35]
MLIGQKIKEIRIEKGISRPDFCGDEQELTVRQLSRIESGASQPSLPKLDYIARRLGVPVYSLMPDFSALPSAYLELKYQI
LREPIYGKEEEYDKKEACLEEIYKTYFDNLPKEEQLACEVLQACLDTSRTRRPEYAELILEEHMPQIIEKEAYSINDMLL
IRLFFYQMLIRKDLAKFINQIEKLMLFLLEQKKVTQIENYFIIRDTLISGMCCLEKVGVTDCFNDYLSCLQEIMDKTQDY
QKKPLVFMFLWKQALREERDFSLAESFYQSSKTFAQLIGDEFLVKKLTEEWQEDVKKYL

Nucleotide

• Length: 900 bp

>NTDB_id=217946 CXP32_RS10120 WP_000904858.1 1900572..1901471(-) (comR) [Streptococcus pneumoniae strain Xen35]
ATGTTAATTGGTCAAAAAATTAAAGAGATTCGGATAGAAAAAGGAATTAGTCGTCCAGATTTTTGTGGAGATGAGCAAGA
ACTGACAGTTCGTCAACTGTCGCGAATTGAAAGTGGAGCTTCGCAACCGAGTTTGCCCAAGTTAGACTATATTGCTCGCC
GGCTAGGAGTTCCAGTTTATAGCCTTATGCCGGATTTTTCAGCTCTTCCTTCTGCTTATTTAGAATTGAAATACCAGATT
TTACGTGAACCAATCTATGGTAAAGAAGAGGAGTACGATAAGAAGGAAGCGTGTTTGGAAGAGATTTATAAAACATACTT
TGATAATCTTCCTAAAGAAGAACAATTAGCATGTGAAGTATTGCAGGCGTGTTTGGATACTTCTAGAACTAGAAGGCCTG
AATATGCAGAGTTAATACTTGAGGAACATATGCCTCAGATTATAGAAAAAGAAGCTTATTCAATAAATGATATGTTGTTG
ATTCGTTTGTTTTTTTATCAAATGCTCATTAGAAAAGATCTTGCCAAATTTATAAATCAAATCGAAAAGCTAATGCTCTT
TCTTTTGGAACAGAAGAAGGTAACTCAAATAGAGAATTACTTTATAATTAGAGATACTCTTATTTCAGGAATGTGTTGTC
TTGAAAAGGTAGGAGTAACTGATTGTTTTAATGATTATCTATCGTGTTTACAAGAAATTATGGATAAAACTCAAGATTAT
CAAAAGAAACCTCTTGTATTTATGTTTTTGTGGAAGCAAGCATTAAGAGAAGAAAGAGATTTTAGTTTAGCTGAATCATT
TTATCAGTCTTCTAAAACATTTGCGCAGCTAATTGGAGATGAATTTCTAGTAAAGAAATTGACAGAGGAATGGCAAGAGG
ATGTCAAAAAATATTTATAA

Domains

Predicted by InterProScan.

• ComR tetratricopeptide (ComR_TPR) (70-291)

3D structure

• AlphaFold DB: A0A0H2URY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	37.755	98.328	0.371
comR	Streptococcus suis P1/7	37.457	97.324	0.365
comR	Streptococcus suis 05ZYH33	37.457	97.324	0.365
comR	Streptococcus pyogenes MGAS8232	36.242	99.666	0.361