Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SPY_RS08760 Genome accession   NC_002737
Coordinates   1771372..1773354 (-) Length   660 a.a.
NCBI ID   WP_010922757.1    Uniprot ID   -
Organism   Streptococcus pyogenes M1 GAS     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1766372..1778354
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPY_RS08735 (SPy2116) recA 1766408..1767544 (-) 1137 WP_010922753.1 recombinase RecA Machinery gene
  SPY_RS08740 (SPy2117) cinA 1767633..1768904 (-) 1272 WP_010922754.1 competence/damage-inducible protein A Machinery gene
  SPY_RS08745 (SPy2118) - 1768973..1769533 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  SPY_RS08750 (SPy2119) ruvA 1769543..1770139 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  SPY_RS08755 (SPy2120) - 1770141..1771361 (-) 1221 WP_010922756.1 MDR family MFS transporter -
  SPY_RS08760 (SPy2121) hexB 1771372..1773354 (-) 1983 WP_010922757.1 DNA mismatch repair endonuclease MutL Machinery gene
  SPY_RS08765 (SPy2122) - 1773449..1774600 (-) 1152 WP_014635780.1 tyrosine-type recombinase/integrase -
  SPY_RS09485 - 1774849..1774992 (+) 144 WP_011185066.1 putative holin-like toxin -
  SPY_RS08775 (SPy2125) irvR 1775853..1776620 (-) 768 WP_003058809.1 LexA family transcriptional regulator Regulator
  SPY_RS08780 (SPy2126) - 1776774..1776980 (+) 207 WP_002992503.1 helix-turn-helix transcriptional regulator -
  SPY_RS08785 (SPy2127) - 1777200..1777781 (+) 582 WP_014635781.1 BRO-N domain-containing protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74285.86 Da        Isoelectric Point: 5.8707

>NTDB_id=21589 SPY_RS08760 WP_010922757.1 1771372..1773354(-) (hexB) [Streptococcus pyogenes M1 GAS]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
VELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=21589 SPY_RS08760 WP_010922757.1 1771372..1773354(-) (hexB) [Streptococcus pyogenes M1 GAS]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAT
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCACCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAATTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GTAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGGGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATAGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)

MutL C terminal dimerisation domain (MutL_C)

(462-604)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.918

100

0.671

Multiple sequence alignment