Detailed information NTG0021378

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: L_RS08735
• Genome accession: NC_002662
• Coordinates: 1725506..1726876 (-)
• Length: 456 a.a.
• NCBI ID: WP_010906089.1
• Uniprot ID: Q9CF07
• Organism: Lactococcus lactis subsp. lactis Il1403
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 1720506..1731876

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L_RS08720 (L121426)	-	1721677..1723110 (-)	1434	WP_010906086.1	6-phospho-beta-glucosidase	-
L_RS08725 (L122982)	yidD	1723233..1723499 (-)	267	WP_010906087.1	membrane protein insertion efficiency factor YidD	-
L_RS08730 (L123365)	-	1723616..1725358 (-)	1743	WP_010906088.1	1-deoxy-D-xylulose-5-phosphate synthase	-
L_RS08735 (L0134)	ciaH	1725506..1726876 (-)	1371	WP_010906089.1	sensor histidine kinase	Regulator
L_RS08740 (L0135)	ciaR	1726969..1727637 (-)	669	WP_021722129.1	response regulator transcription factor	Regulator
L_RS08745 (L0144)	-	1727815..1728789 (-)	975	WP_003130365.1	LacI family DNA-binding transcriptional regulator	-
L_RS08750 (L128690)	-	1728942..1731197 (-)	2256	WP_010906090.1	glycoside hydrolase family 65 protein	-

Sequence

Protein

• Length: 456 a.a.
• Molecular weight: 51278.80 Da
• Isoelectric Point: 9.3135

>NTDB_id=21378 L_RS08735 WP_010906089.1 1725506..1726876(-) (ciaH) [Lactococcus lactis subsp. lactis Il1403]
MKKIIKKVKSSAIVKNDGKNFLHFFLAFTVIFVALAVIIIQVMQLGMYRATDQNLHNLAQNRVFLIEAANNQLGMNNSQD
SGYYGPNNSVIFYDSEGKSFIPSAGSNANISTNFGMSLLQKTMKFNENQINTIQTVSVKNPYGDNWHYRYLTTSQFIITN
TDGTVTPVYAQIFSNVDQIQDAMSRAMWVIVTTMITFWLLSVIISLYLANWTLKPILAAYEKQKEFVENASHELRTPLAI
LQNRLELLFQKPTATIIDESENISESLSEVRNMRLLTSNLLNLARRDSGIRIEPEATTATYFENIFNSYEMLAENAGKKF
SGDLKLDGTINLDQALIKQLLTILFDNALKYTGDEGEISVDVQKNGGFLVFAVADNGEGISDEDKKKIFDRFFRVDKART
RQKGGLGLGLSLAKQIVEAYNGKITVEDNKPKGTKFIVRIRVDSTISNPAKIFQKL

Nucleotide

• Length: 1371 bp

>NTDB_id=21378 L_RS08735 WP_010906089.1 1725506..1726876(-) (ciaH) [Lactococcus lactis subsp. lactis Il1403]
TTGAAGAAAATAATTAAAAAAGTTAAATCTTCAGCTATTGTAAAAAATGATGGGAAAAATTTCCTTCATTTTTTTCTAGC
TTTTACAGTCATTTTTGTTGCTTTAGCCGTGATTATTATTCAAGTCATGCAATTAGGAATGTATCGAGCGACTGACCAAA
ATTTACACAATTTGGCTCAAAACCGAGTCTTTTTGATAGAAGCAGCGAATAATCAATTAGGAATGAATAATTCGCAAGAT
AGTGGCTATTACGGTCCCAATAATAGTGTAATTTTTTATGATTCAGAGGGTAAAAGTTTCATACCTTCAGCGGGTTCAAA
TGCAAATATAAGTACAAATTTTGGCATGAGCCTTCTGCAAAAAACAATGAAATTTAACGAAAATCAAATTAACACTATTC
AAACTGTTTCTGTAAAAAATCCTTATGGAGATAATTGGCACTATCGTTATCTGACAACATCACAATTTATTATTACAAAT
ACTGATGGAACAGTAACTCCGGTTTATGCACAAATTTTTTCAAATGTTGACCAAATTCAAGATGCCATGAGCCGAGCCAT
GTGGGTCATTGTGACAACAATGATTACTTTCTGGCTTCTGTCAGTAATTATTAGTCTATATCTTGCAAACTGGACATTAA
AACCAATTTTGGCCGCTTATGAAAAACAAAAAGAATTTGTTGAAAATGCTTCACATGAATTGAGAACACCTCTGGCAATC
TTGCAAAATCGTCTAGAATTACTTTTCCAAAAGCCAACAGCAACAATTATTGATGAATCAGAAAATATTTCTGAAAGTTT
ATCAGAAGTTCGTAATATGCGTTTATTAACAAGTAACTTACTGAACTTAGCTCGTCGAGATTCTGGAATCAGAATTGAGC
CAGAGGCGACTACGGCAACTTATTTTGAGAATATTTTTAATAGCTATGAAATGCTTGCTGAAAACGCAGGTAAAAAGTTT
TCAGGCGATTTGAAATTAGATGGAACGATTAATTTGGACCAAGCCCTGATTAAACAATTGCTAACCATCTTATTTGATAA
TGCTCTTAAATACACGGGTGATGAGGGTGAAATCTCTGTAGATGTTCAAAAAAATGGGGGATTCTTAGTTTTTGCTGTCG
CCGATAATGGTGAAGGAATTTCTGATGAAGATAAGAAAAAAATCTTTGACCGCTTTTTCCGAGTAGATAAAGCAAGAACG
CGTCAAAAAGGTGGCTTAGGTTTGGGTCTTTCTCTGGCCAAACAAATTGTTGAAGCTTACAATGGGAAGATTACAGTTGA
AGATAATAAACCTAAAGGTACAAAATTCATTGTTAGAATTCGTGTGGATAGCACAATTTCAAATCCTGCAAAAATTTTCC
AAAAGTTGTAA

Domains

Predicted by InterProScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (333-442)

• His Kinase A (phospho-acceptor) domain (HisKA) (223-289)

3D structure

• AlphaFold DB: Q9CF07

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	48.837	94.298	0.461
ciaH	Streptococcus pneumoniae Rx1	44.321	98.465	0.436
ciaH	Streptococcus pneumoniae D39	44.321	98.465	0.436
ciaH	Streptococcus pneumoniae R6	44.321	98.465	0.436
ciaH	Streptococcus pneumoniae TIGR4	44.321	98.465	0.436