Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   COG38_RS13885 Genome accession   NZ_CP024263
Coordinates   2700256..2700915 (+) Length   219 a.a.
NCBI ID   WP_001221488.1    Uniprot ID   -
Organism   Escherichia coli O169:H41 strain F6326-C1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2695256..2705915
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  COG38_RS13860 plsC 2695402..2696139 (-) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -
  COG38_RS13865 parC 2696373..2698631 (-) 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
  COG38_RS13875 ygiV 2699177..2699659 (-) 483 WP_001718874.1 GyrI-like domain-containing protein -
  COG38_RS13880 ygiW 2699712..2700104 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  COG38_RS13885 ciaR 2700256..2700915 (+) 660 WP_001221488.1 quorum sensing response regulator transcription factor QseB Regulator
  COG38_RS13890 qseC 2700912..2702261 (+) 1350 WP_000673355.1 quorum sensing histidine kinase QseC -
  COG38_RS13895 ygiZ 2702312..2702644 (-) 333 WP_024171565.1 DUF2645 family protein -
  COG38_RS13900 mdaB 2703002..2703583 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  COG38_RS13905 ygiN 2703614..2703928 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  COG38_RS13910 - 2703973..2704860 (-) 888 WP_000614954.1 MurR/RpiR family transcriptional regulator -
  COG38_RS13915 - 2704857..2705804 (-) 948 WP_001305988.1 iron-siderophore ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24692.61 Da        Isoelectric Point: 6.3527

>NTDB_id=212280 COG38_RS13885 WP_001221488.1 2700256..2700915(+) (ciaR) [Escherichia coli O169:H41 strain F6326-C1]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQCEPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=212280 COG38_RS13885 WP_001221488.1 2700256..2700915(+) (ciaR) [Escherichia coli O169:H41 strain F6326-C1]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGTGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment