Detailed information NTG0020880

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: SPY_RS05175
• Genome accession: NC_002737
• Coordinates: 1018020..1019330 (-)
• Length: 436 a.a.
• NCBI ID: WP_010922354.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes M1 GAS
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 1013020..1024330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPY_RS05150 (SPy1228)	-	1013624..1014676 (-)	1053	WP_002989701.1	BMP family lipoprotein	-
SPY_RS05155 (SPy1230)	-	1014770..1015159 (-)	390	WP_010922351.1	cytidine deaminase	-
SPY_RS05160 (SPy1232)	-	1015812..1016405 (-)	594	WP_010922352.1	class I SAM-dependent methyltransferase	-
SPY_RS05165 (SPy1233)	coaA	1016673..1017593 (+)	921	WP_010922353.1	type I pantothenate kinase	-
SPY_RS05170 (SPy1234)	rpsT	1017647..1017895 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
SPY_RS05175 (SPy1236)	ciaH	1018020..1019330 (-)	1311	WP_010922354.1	sensor histidine kinase	Regulator
SPY_RS05180 (SPy1237)	ciaR	1019323..1019997 (-)	675	WP_010922355.1	response regulator transcription factor	Regulator
SPY_RS05185 (SPy1239)	-	1020343..1022880 (-)	2538	WP_010922356.1	M1 family metallopeptidase	-
SPY_RS05190 (SPy1240)	phoU	1023085..1023738 (-)	654	WP_010922357.1	phosphate signaling complex protein PhoU	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50013.52 Da
• Isoelectric Point: 9.0831

>NTDB_id=20880 SPY_RS05175 WP_010922354.1 1018020..1019330(-) (ciaH) [Streptococcus pyogenes M1 GAS]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVGVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=20880 SPY_RS05175 WP_010922354.1 1018020..1019330(-) (ciaH) [Streptococcus pyogenes M1 GAS]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAGGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516