Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SMA_2121 Genome accession   HE613569
Coordinates   2059468..2061411 (-) Length   647 a.a.
NCBI ID   CCF03412.1    Uniprot ID   -
Organism   Streptococcus macedonicus ACA-DC 198     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2054468..2066411
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMA_2113 cinA 2054650..2055909 (-) 1260 CCF03404.1 Competence/damage-inducible protein CinA Machinery gene
  SMA_2114 - 2056067..2056504 (-) 438 CCF03405.1 Facilitator superfamily protein -
  SMA_2115 - 2056443..2056673 (-) 231 CCF03406.1 Facilitator superfamily protein -
  SMA_2116 - 2056631..2057005 (-) 375 CCF03407.1 Facilitator superfamily protein -
  SMA_2117 - 2057387..2057689 (-) 303 CCF03408.1 Hypothetical protein -
  SMA_2118 - 2057708..2057851 (-) 144 CCF03409.1 Hypothetical protein -
  SMA_2119 - 2058112..2058768 (+) 657 CCF03410.1 Hypothetical protein -
  SMA_2120 ruvA 2058873..2059466 (-) 594 CCF03411.1 Holliday junction DNA helicase RuvA Machinery gene
  SMA_2121 hexB 2059468..2061411 (-) 1944 CCF03412.1 DNA mismatch repair protein MutL Machinery gene
  SMA_2122 hexA 2061528..2064098 (-) 2571 CCF03413.1 DNA mismatch repair protein MutS Machinery gene
  SMA_2123 - 2064085..2064441 (-) 357 CCF03414.1 Hypothetical protein -
  SMA_2124 argR2 2064438..2064875 (-) 438 CCF03415.1 Arginine repressor ArgR, putative -

Sequence

Protein


Download         Length: 647 a.a.        Molecular weight: 73334.41 Da        Isoelectric Point: 4.9925

>NTDB_id=20699 SMA_2121 CCF03412.1 2059468..2061411(-) (hexB) [Streptococcus macedonicus ACA-DC 198]
MSKIIELPEVLANQIAAGEVIERPASVVKELVENSIDAGSSQITIEIEEAGLKKIQVTDNGEGITQDDVALSLHRHATSK
IKNQADLFRIRTLGFRGEAIPSIASISHFTVKTATADENYGTLLVAKGGEIEKQEPISTPVGTKIMVENLFYNTPARLKY
MKSLQSELAHIVDVVNRLSLAHPEVAFSLINDGRQMTTTSGTGDLRQAIAGIYGLNTAKKMIEISNADLDFEVSGYIGLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMSLISS
AIAESLREQDLIPDALENLAKSSTRGLPKPEQTSLPLKQTDLYYDKERRDFFVKSDTVEEQPVQLFNEVDNSVKEVDKQQ
TSVKYAQRSEVDSQDDEHDNLDFKNKTKINNMIESLDNEESSTFPELDYFGQMHGTYLFAQGNGGLYIIDQHAAQERVKY
EYYREKIGDVDSSLQQLLMPYLFEFSGADFIKLQEKMELLNQVDIYLEPYGNNTFILREHPIWMKEEEIETAVYEMCDML
LLTNEVSVKKYRAELAIMMSCKRSIKANHILDDYSARHLLVQLSQCKNPYNCPHGRPVLVNFTKADMEKMFRRIQENHTS
LRELGKY

Nucleotide


Download         Length: 1944 bp        

>NTDB_id=20699 SMA_2121 CCF03412.1 2059468..2061411(-) (hexB) [Streptococcus macedonicus ACA-DC 198]
ATGAGTAAAATTATTGAGTTGCCAGAGGTTTTGGCTAACCAAATTGCGGCGGGTGAAGTTATTGAACGACCAGCTAGCGT
TGTCAAAGAATTGGTGGAAAATTCGATCGATGCAGGGAGCAGCCAAATCACCATTGAAATTGAAGAAGCTGGTTTAAAGA
AAATTCAAGTGACAGATAATGGCGAAGGAATTACTCAAGATGATGTTGCGTTAAGTCTGCACCGCCATGCCACAAGTAAA
ATTAAAAATCAAGCTGACCTTTTCCGTATAAGGACATTAGGTTTTCGTGGTGAAGCGATACCGTCAATTGCCTCCATTAG
TCATTTTACAGTCAAAACAGCAACGGCAGATGAAAATTATGGAACATTGCTAGTAGCCAAAGGTGGTGAAATTGAAAAAC
AAGAACCGATTTCTACACCCGTTGGAACCAAAATTATGGTTGAAAATCTCTTTTATAATACGCCAGCGCGTCTTAAATAC
ATGAAAAGTCTCCAATCCGAATTAGCTCATATTGTTGATGTGGTGAATCGTTTGAGCTTGGCGCACCCAGAGGTGGCTTT
TAGCTTGATTAATGATGGTCGTCAAATGACAACAACATCTGGCACTGGTGATTTGCGACAAGCAATTGCTGGTATTTATG
GGCTTAATACGGCTAAAAAAATGATTGAGATTTCGAATGCTGACCTCGATTTTGAAGTGTCTGGTTACATTGGTCTGCCA
GAATTGACACGAGCGAACCGAAACTATATTACGATTTTGATTAACGGTCGTTATATTAAAAACTTTTTGCTCAATCGTGC
GATTTTGGACGGTTATGGTTCAAAATTGATGGTGGGACGTTTTCCGATTGCTGTTATCGACATTCAAATCGACCCTTATT
TAGCTGATGTCAATGTTCACCCAACGAAGCAAGAAGTTCGTATCTCAAAGGAAAAAGAACTGATGAGCTTAATCAGCTCT
GCTATTGCAGAGAGTCTGCGTGAGCAAGATTTGATACCTGATGCTCTAGAAAATCTGGCGAAATCAAGCACACGTGGGCT
TCCGAAACCAGAGCAAACGAGCCTGCCGTTGAAACAAACAGATCTTTATTATGATAAAGAACGTCGTGATTTCTTTGTCA
AGTCAGATACGGTTGAAGAGCAACCAGTACAGTTATTCAATGAGGTTGACAACTCTGTCAAGGAAGTTGACAAACAACAA
ACATCAGTGAAATATGCGCAGCGTTCCGAAGTAGATAGTCAAGATGATGAACATGATAATCTCGATTTTAAAAACAAGAC
AAAAATCAATAATATGATTGAAAGCCTTGATAATGAGGAGTCATCAACTTTCCCAGAATTAGATTATTTCGGACAAATGC
ACGGAACGTATCTTTTTGCACAGGGAAATGGTGGGCTTTATATCATTGACCAACACGCTGCTCAAGAACGTGTTAAATAT
GAATATTATCGTGAGAAAATCGGCGACGTTGACAGCTCTTTACAGCAGCTTCTCATGCCATACCTTTTTGAGTTTTCTGG
AGCTGATTTTATTAAGTTGCAAGAAAAAATGGAGCTGTTAAATCAAGTTGATATTTATCTAGAACCATATGGAAACAACA
CTTTTATTCTCCGTGAACACCCAATTTGGATGAAAGAAGAGGAAATTGAGACGGCTGTTTATGAGATGTGTGATATGCTG
TTGTTGACAAATGAAGTATCGGTGAAGAAATATCGTGCAGAATTGGCAATCATGATGTCATGCAAACGCTCAATCAAAGC
GAATCACATTCTTGATGATTATTCCGCCCGACATCTTTTGGTTCAGTTATCACAATGTAAGAATCCTTATAACTGTCCAC
ATGGACGTCCAGTTCTTGTCAACTTTACCAAAGCTGACATGGAAAAAATGTTCCGCCGTATTCAAGAAAATCACACAAGT
TTAAGAGAGTTAGGAAAATACTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(449-591)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

70.291

100

0.709

Multiple sequence alignment