Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CNQ48_RS03975 Genome accession   NZ_CP023386
Coordinates   785325..785984 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain 1190     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 780325..790984
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CNQ48_RS03950 (CNQ48_03950) ygiN 781226..781540 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  CNQ48_RS03955 (CNQ48_03955) mdaB 781571..782152 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  CNQ48_RS26145 - 782402..782881 (+) 480 WP_000065335.1 Hcp family type VI secretion system effector -
  CNQ48_RS26150 - 782884..783594 (+) 711 WP_000834027.1 hypothetical protein -
  CNQ48_RS03965 (CNQ48_03965) - 783601..783933 (+) 333 WP_000914697.1 DUF2645 family protein -
  CNQ48_RS03970 (CNQ48_03970) qseC 783979..785328 (-) 1350 WP_000673375.1 quorum sensing histidine kinase QseC -
  CNQ48_RS03975 (CNQ48_03975) ciaR 785325..785984 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  CNQ48_RS03980 (CNQ48_03980) ygiW 786136..786528 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  CNQ48_RS03985 (CNQ48_03985) ygiV 786581..787063 (+) 483 WP_000183490.1 GyrI-like domain-containing protein -
  CNQ48_RS03995 (CNQ48_03995) parC 787609..789867 (+) 2259 WP_001281890.1 DNA topoisomerase IV subunit A -
  CNQ48_RS04000 (CNQ48_04000) plsC 790101..790838 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=206771 CNQ48_RS03975 WP_001221493.1 785325..785984(-) (ciaR) [Escherichia coli strain 1190]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=206771 CNQ48_RS03975 WP_001221493.1 785325..785984(-) (ciaR) [Escherichia coli strain 1190]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGTGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGTTAGCGGAACGTGTAGAGGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACACTGGCTGGTGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365