Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   CLC88_RS20230 Genome accession   NZ_CP023165
Coordinates   3967759..3968391 (+) Length   210 a.a.
NCBI ID   WP_000242755.1    Uniprot ID   A0A1C4FZU4
Organism   Escherichia coli O22:H8 strain RM10809-3     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 3962759..3973391
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CLC88_RS20205 (CLC88_20710) yheS 3962928..3964841 (+) 1914 WP_000634789.1 ABC transporter ATP-binding protein -
  CLC88_RS20210 (CLC88_20715) yheT 3964841..3965863 (+) 1023 WP_000057379.1 hydrolase -
  CLC88_RS20215 (CLC88_20720) yheU 3965857..3966075 (+) 219 WP_000907085.1 YheU family protein -
  CLC88_RS20220 (CLC88_20725) prkB 3966129..3966998 (+) 870 WP_001274680.1 phosphoribulokinase -
  CLC88_RS20225 (CLC88_20730) yhfA 3967053..3967457 (-) 405 WP_001148908.1 OsmC family protein -
  CLC88_RS20230 (CLC88_20735) crp 3967759..3968391 (+) 633 WP_000242755.1 cAMP-activated global transcriptional regulator CRP Regulator
  CLC88_RS20235 (CLC88_20740) yhfK 3968442..3970532 (+) 2091 WP_001295162.1 YccS/YhfK family putative transporter -
  CLC88_RS20240 (CLC88_20745) argD 3970599..3971819 (-) 1221 WP_000963797.1 bifunctional acetylornithine/succinyldiaminopimelate transaminase -
  CLC88_RS20245 (CLC88_20750) pabA 3971905..3972468 (-) 564 WP_000601847.1 aminodeoxychorismate synthase component 2 -
  CLC88_RS20250 (CLC88_20755) fic 3972500..3973102 (-) 603 WP_001280624.1 putative adenosine monophosphate-protein transferase Fic -
  CLC88_RS20255 (CLC88_20760) yhfG 3973092..3973259 (-) 168 WP_000736860.1 YhfG family protein -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23640.43 Da        Isoelectric Point: 8.2710

>NTDB_id=205480 CLC88_RS20230 WP_000242755.1 3967759..3968391(+) (crp) [Escherichia coli O22:H8 strain RM10809-3]
MVLGKPQTDPTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGDFIGELGLFEEG
QERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTSEKVGNLAFLDVTGRIAQTLLNLAKQPDAMTH
PDGMQIKITRQEIGQIVGCSRETVGRILKMLEDQNLISAHGKTIVVYGTR

Nucleotide


Download         Length: 633 bp        

>NTDB_id=205480 CLC88_RS20230 WP_000242755.1 3967759..3968391(+) (crp) [Escherichia coli O22:H8 strain RM10809-3]
ATGGTGCTTGGCAAACCGCAAACAGACCCGACTCTCGAATGGTTCTTGTCTCATTGCCACATTCATAAGTACCCATCCAA
GAGCACGCTTATTCACCAGGGTGAAAAAGCGGAAACGCTGTACTACATCGTTAAAGGCTCTGTGGCAGTGCTGATCAAAG
ACGAAGAGGGTAAAGAAATGATCCTCTCCTATCTGAATCAGGGTGATTTTATTGGCGAACTGGGCCTGTTTGAAGAGGGC
CAGGAACGTAGCGCATGGGTACGTGCGAAAACCGCCTGTGAAGTGGCTGAAATTTCGTACAAAAAATTTCGCCAATTGAT
TCAGGTAAACCCGGACATTCTGATGCGTCTGTCTGCACAGATGGCGCGTCGTCTGCAAGTCACTTCAGAGAAAGTGGGCA
ACCTGGCGTTCCTCGACGTGACGGGCCGCATTGCACAGACTCTGCTGAACCTGGCAAAACAACCAGATGCTATGACTCAC
CCGGACGGTATGCAAATCAAAATTACCCGTCAGGAAATCGGTCAGATTGTCGGCTGTTCTCGTGAAACCGTGGGACGCAT
TCTGAAGATGCTGGAAGATCAGAACCTGATCTCCGCACACGGTAAAACCATCGTCGTTTACGGCACTCGTTAA

Domains

Predicted by InterProScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(23-109)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(142-206)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1C4FZU4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Vibrio cholerae strain A1552

95.714

100

0.957
  crp Haemophilus influenzae Rd KW20

77.941

97.143

0.757
  crp Acinetobacter baumannii D1279779

47.343

98.571

0.467

Multiple sequence alignment