Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   A2U18_RS10505 Genome accession   NZ_CP017091
Coordinates   2033389..2034018 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus strain ISU926 isolate ST398     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2028389..2039018
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A2U18_RS10475 (A2U18_10155) - 2028809..2029339 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  A2U18_RS10480 (A2U18_10160) - 2029429..2030685 (-) 1257 WP_001793428.1 aminopeptidase -
  A2U18_RS10485 (A2U18_10165) - 2030688..2030888 (-) 201 WP_000180460.1 DUF1128 family protein -
  A2U18_RS10490 (A2U18_10170) - 2031035..2031499 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  A2U18_RS10495 (A2U18_10175) - 2031506..2031781 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  A2U18_RS10500 (A2U18_10180) - 2032059..2033276 (+) 1218 WP_000037081.1 YihY/virulence factor BrkB family protein -
  A2U18_RS10505 (A2U18_10185) vraR 2033389..2034018 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  A2U18_RS10510 (A2U18_10190) vraS 2034008..2035051 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  A2U18_RS10515 (A2U18_10195) liaF 2035048..2035749 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  A2U18_RS10520 (A2U18_10200) - 2035764..2036150 (-) 387 WP_001110182.1 hypothetical protein -
  A2U18_RS10525 (A2U18_10205) map 2036367..2037125 (-) 759 WP_000636145.1 type I methionyl aminopeptidase -
  A2U18_RS10535 (A2U18_10215) - 2037709..2038695 (+) 987 WP_000999712.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=195502 A2U18_RS10505 WP_000153535.1 2033389..2034018(-) (vraR) [Staphylococcus aureus strain ISU926 isolate ST398]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=195502 A2U18_RS10505 WP_000153535.1 2033389..2034018(-) (vraR) [Staphylococcus aureus strain ISU926 isolate ST398]
ATGACGATTAAAGTATTATTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATATTAA
TGGATTTACTTATGGAAGACATGGATGGAGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
TAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment