Detailed information NTG0195503

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A2U18_RS10510
• Genome accession: NZ_CP017091
• Coordinates: 2034008..2035051 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain ISU926 isolate ST398
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2029008..2040051

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A2U18_RS10480 (A2U18_10160)	-	2029429..2030685 (-)	1257	WP_001793428.1	aminopeptidase	-
A2U18_RS10485 (A2U18_10165)	-	2030688..2030888 (-)	201	WP_000180460.1	DUF1128 family protein	-
A2U18_RS10490 (A2U18_10170)	-	2031035..2031499 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
A2U18_RS10495 (A2U18_10175)	-	2031506..2031781 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
A2U18_RS10500 (A2U18_10180)	-	2032059..2033276 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
A2U18_RS10505 (A2U18_10185)	vraR	2033389..2034018 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
A2U18_RS10510 (A2U18_10190)	vraS	2034008..2035051 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
A2U18_RS10515 (A2U18_10195)	liaF	2035048..2035749 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
A2U18_RS10520 (A2U18_10200)	-	2035764..2036150 (-)	387	WP_001110182.1	hypothetical protein	-
A2U18_RS10525 (A2U18_10205)	map	2036367..2037125 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
A2U18_RS10535 (A2U18_10215)	-	2037709..2038695 (+)	987	WP_000999712.1	FUSC family protein	-
A2U18_RS10540 (A2U18_10220)	-	2038884..2039297 (-)	414	WP_025174370.1	hypothetical protein	-
A2U18_RS10545 (A2U18_10225)	-	2039326..2039436 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=195503 A2U18_RS10510 WP_001017131.1 2034008..2035051(-) (vraS) [Staphylococcus aureus strain ISU926 isolate ST398]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=195503 A2U18_RS10510 WP_001017131.1 2034008..2035051(-) (vraS) [Staphylococcus aureus strain ISU926 isolate ST398]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1