Detailed information NTG0190512

Bioinformatically predicted

Overview

• Name: dsbA2
• Type: Machinery gene
• Locus tag: A6L40_RS06830
• Genome accession: NZ_CP016656
• Coordinates: 1291280..1291975 (+)
• Length: 231 a.a.
• NCBI ID: WP_002215704.1
• Uniprot ID: Q7DDR6
• Organism: Neisseria meningitidis strain M22769
• Function: DNA binding and uptake; interact with PilQ (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1290450..1308463	1291280..1291975	within	0

Gene organization within MGE regions

Location: 1290450..1308463

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6L40_RS06825 (A6L40_06825)	-	1290450..1291109 (+)	660	WP_002218694.1	NYN domain-containing protein	-
A6L40_RS06830 (A6L40_06830)	dsbA2	1291280..1291975 (+)	696	WP_002215704.1	thiol:disulfide interchange protein DsbA/DsbL	Machinery gene
A6L40_RS06835 (A6L40_06835)	ffh	1292306..1293676 (-)	1371	WP_002221448.1	signal recognition particle protein	-
A6L40_RS06840 (A6L40_06840)	-	1293896..1294702 (+)	807	WP_002221447.1	cytochrome C assembly family protein	-
A6L40_RS06875 (A6L40_06875)	comE	1300501..1300965 (+)	465	WP_025463168.1	ComEA family DNA-binding protein	Machinery gene
A6L40_RS06880 (A6L40_06880)	-	1301077..1301283 (+)	207	WP_025461473.1	hypothetical protein	-
A6L40_RS06890 (A6L40_06890)	-	1301841..1302494 (+)	654	WP_002241060.1	IS1595 family transposase	-
A6L40_RS06895 (A6L40_06895)	-	1302659..1302868 (+)	210	Protein_1301	transposase	-
A6L40_RS06900 (A6L40_06900)	-	1302850..1303107 (-)	258	WP_002241061.1	membrane protein	-
A6L40_RS06905 (A6L40_06905)	aroG	1303774..1304829 (+)	1056	WP_002216371.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
A6L40_RS06910 (A6L40_06910)	-	1304897..1305385 (+)	489	WP_002216373.1	dihydrofolate reductase	-
A6L40_RS06915 (A6L40_06915)	-	1305734..1306210 (-)	477	WP_002241062.1	CYTH domain-containing protein	-
A6L40_RS06920 (A6L40_06920)	-	1306222..1306650 (-)	429	WP_002261574.1	CopD family protein	-
A6L40_RS06930 (A6L40_06930)	-	1306762..1307007 (+)	246	WP_002248225.1	hypothetical protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 25419.90 Da
• Isoelectric Point: 5.1502

>NTDB_id=190512 A6L40_RS06830 WP_002215704.1 1291280..1291975(+) (dsbA2) [Neisseria meningitidis strain M22769]
MKLKTLALTSLTLLALAACSKQAETSVPADSAQSSSSAPAAPAELNEGVNYTVLSTPIPQQQAGKIEVLEFFGYFCPHCA
HLEPVLSEHIKTFKDDTYMRREHVVWGDEMKPLARLAAAVEMAGESDKANSHIFDAMVNQKINLADTDTLKKWLSEQTAF
DGKKVLAAFEAPESQARAAQMEELTNKFQISGTPTVIVGGKYQVEFKDWQSGMTTIDQLVDKVREEQKKPQ

Nucleotide

• Length: 696 bp

>NTDB_id=190512 A6L40_RS06830 WP_002215704.1 1291280..1291975(+) (dsbA2) [Neisseria meningitidis strain M22769]
ATGAAACTGAAAACCTTAGCTTTGACTTCATTGACCCTGTTGGCATTGGCCGCTTGTAGCAAACAGGCTGAAACCAGTGT
TCCGGCAGACAGCGCCCAAAGCAGCTCATCTGCTCCGGCAGCCCCTGCTGAGTTGAACGAAGGTGTGAACTACACTGTAT
TGTCTACGCCTATTCCGCAACAGCAGGCCGGTAAAATCGAAGTATTGGAATTTTTCGGCTACTTCTGCCCGCATTGCGCC
CATCTTGAGCCGGTCTTGAGCGAGCACATCAAAACGTTTAAAGACGATACCTATATGCGCCGGGAGCATGTCGTGTGGGG
TGATGAAATGAAACCTTTGGCACGTTTGGCGGCCGCAGTGGAAATGGCCGGTGAATCAGATAAAGCCAACAGCCATATTT
TCGATGCGATGGTTAATCAAAAAATCAATCTGGCCGATACCGATACCCTGAAAAAATGGCTGTCCGAGCAAACAGCGTTT
GACGGCAAAAAAGTATTGGCTGCATTTGAGGCTCCTGAAAGCCAAGCGCGTGCGGCTCAAATGGAAGAGTTGACCAATAA
ATTCCAAATCAGCGGCACACCGACTGTGATTGTCGGCGGCAAATACCAAGTTGAATTTAAAGACTGGCAGTCTGGTATGA
CCACGATTGACCAGTTGGTGGATAAAGTACGCGAAGAGCAGAAAAAGCCGCAATAA

Domains

Predicted by InterproScan.

• Thioredoxin (Thioredoxin_4) (65-212)

3D structure

• AlphaFold DB: Q7DDR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dsbA2	Neisseria meningitidis MC58	100	100	1
dsbA1	Neisseria meningitidis MC58	71.245	100	0.719