Detailed information
Bioinformatically predicted
Overview
| Name | comE | Type | Machinery gene |
| Locus tag | A6L32_RS03485 | Genome accession | NZ_CP016627 |
| Coordinates | 669735..670199 (-) | Length | 154 a.a. |
| NCBI ID | WP_011798742.1 | Uniprot ID | - |
| Organism | Neisseria meningitidis strain M22718 | ||
| Function | DNA binding (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 646824..692938 | 669735..670199 | within | 0 |
Gene organization within MGE regions
Location: 646824..692938
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6L32_RS03385 (A6L32_03385) | - | 646824..647993 (-) | 1170 | WP_019273883.1 | DUF6716 putative glycosyltransferase | - |
| A6L32_RS03390 (A6L32_03390) | - | 648043..648720 (-) | 678 | WP_002215827.1 | IS1595-like element ISNme3 family transposase | - |
| A6L32_RS03395 (A6L32_03395) | - | 648991..652104 (-) | 3114 | WP_002248201.1 | glycosyltransferase | - |
| A6L32_RS03400 (A6L32_03400) | siaC | 652256..653305 (-) | 1050 | WP_002228845.1 | polysialic acid capsule biosynthesis protein SiaC | - |
| A6L32_RS03405 (A6L32_03405) | neuA | 653306..653992 (-) | 687 | WP_002215295.1 | N-acylneuraminate cytidylyltransferase | - |
| A6L32_RS03410 (A6L32_03410) | neuC | 653996..655129 (-) | 1134 | WP_033908889.1 | UDP-N-acetylglucosamine 2-epimerase | - |
| A6L32_RS03415 (A6L32_03415) | ctrA | 655264..656439 (+) | 1176 | WP_002215290.1 | capsule polysaccharide export outer membrane protein CtrA | - |
| A6L32_RS03420 (A6L32_03420) | ctrB | 656454..657617 (+) | 1164 | WP_002215287.1 | capsule polysaccharide export protein CtrB | - |
| A6L32_RS03425 (A6L32_03425) | - | 657617..658414 (+) | 798 | WP_002215286.1 | ABC transporter permease | - |
| A6L32_RS03430 (A6L32_03430) | - | 658411..659061 (+) | 651 | WP_002220117.1 | ABC transporter ATP-binding protein | - |
| A6L32_RS03435 (A6L32_03435) | - | 659126..661399 (+) | 2274 | WP_002248203.1 | Tex family protein | - |
| A6L32_RS03440 (A6L32_03440) | - | 661430..662428 (+) | 999 | WP_002220118.1 | DNA cytosine methyltransferase | - |
| A6L32_RS03445 (A6L32_03445) | - | 662421..662765 (+) | 345 | WP_002228843.1 | DNA adenine methylase | - |
| A6L32_RS03450 (A6L32_03450) | galE | 662844..663464 (+) | 621 | Protein_657 | UDP-glucose 4-epimerase GalE | - |
| A6L32_RS03455 (A6L32_03455) | rfbB | 663465..664547 (+) | 1083 | WP_002224375.1 | dTDP-glucose 4,6-dehydratase | - |
| A6L32_RS03460 (A6L32_03460) | rfbA | 664610..665476 (+) | 867 | WP_002224369.1 | glucose-1-phosphate thymidylyltransferase RfbA | - |
| A6L32_RS03465 (A6L32_03465) | rfbC | 665530..666087 (+) | 558 | WP_002224368.1 | dTDP-4-dehydrorhamnose 3,5-epimerase | - |
| A6L32_RS03470 (A6L32_03470) | - | 666131..668149 (-) | 2019 | WP_002224367.1 | OPT family oligopeptide transporter | - |
| A6L32_RS03475 (A6L32_03475) | dnaJ | 668345..669466 (-) | 1122 | WP_002215274.1 | molecular chaperone DnaJ | - |
| A6L32_RS03485 (A6L32_03485) | comE | 669735..670199 (-) | 465 | WP_011798742.1 | ComEA family DNA-binding protein | Machinery gene |
| A6L32_RS03520 (A6L32_03520) | dksA | 675999..676415 (-) | 417 | WP_002215267.1 | RNA polymerase-binding protein DksA | - |
| A6L32_RS03525 (A6L32_03525) | proC | 676562..677353 (-) | 792 | WP_002215263.1 | pyrroline-5-carboxylate reductase | - |
| A6L32_RS03530 (A6L32_03530) | - | 677402..677809 (-) | 408 | WP_002242150.1 | hypothetical protein | - |
| A6L32_RS03535 (A6L32_03535) | - | 677809..678495 (-) | 687 | WP_002242149.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
| A6L32_RS03540 (A6L32_03540) | pilT | 678615..679658 (+) | 1044 | WP_002226887.1 | type IV pilus twitching motility protein PilT | Machinery gene |
| A6L32_RS03545 (A6L32_03545) | - | 679821..681047 (+) | 1227 | WP_002218483.1 | PilT/PilU family type 4a pilus ATPase | - |
| A6L32_RS03550 (A6L32_03550) | yccS | 681333..683483 (+) | 2151 | WP_002248193.1 | YccS family putative transporter | - |
| A6L32_RS03560 (A6L32_03560) | - | 684703..685911 (+) | 1209 | WP_002212532.1 | replication initiation factor domain-containing protein | - |
| A6L32_RS03565 (A6L32_03565) | - | 685932..686243 (+) | 312 | WP_002212531.1 | hypothetical protein | - |
| A6L32_RS03570 (A6L32_03570) | - | 686247..686447 (+) | 201 | WP_002212530.1 | hypothetical protein | - |
| A6L32_RS03575 (A6L32_03575) | - | 686674..686904 (+) | 231 | WP_002216898.1 | hypothetical protein | - |
| A6L32_RS03580 (A6L32_03580) | - | 686932..687234 (+) | 303 | WP_002226957.1 | hypothetical protein | - |
| A6L32_RS14000 | - | 687350..687631 (+) | 282 | WP_002212527.1 | hypothetical protein | - |
| A6L32_RS03585 (A6L32_03585) | - | 687582..689186 (+) | 1605 | WP_033909464.1 | IgG-binding virulence factor TspB family protein | - |
| A6L32_RS03590 (A6L32_03590) | - | 689489..689773 (+) | 285 | WP_002216892.1 | DUF2523 domain-containing protein | - |
| A6L32_RS03595 (A6L32_03595) | - | 689774..690961 (+) | 1188 | WP_002212523.1 | zonular occludens toxin family protein | - |
| A6L32_RS03600 (A6L32_03600) | - | 691176..692132 (+) | 957 | WP_002212521.1 | IS110-like element ISNgo3 family transposase | - |
| A6L32_RS03610 (A6L32_03610) | - | 692654..692938 (-) | 285 | WP_002216166.1 | GIY-YIG nuclease family protein | - |
Sequence
Protein
Download Length: 154 a.a. Molecular weight: 16605.84 Da Isoelectric Point: 10.8773
>NTDB_id=189767 A6L32_RS03485 WP_011798742.1 669735..670199(-) (comE) [Neisseria meningitidis strain M22718]
MLYPEKMSGMAGRHPYGVRSGLRRNGLKLWDIHFRMTRFIVARCGLLFATLKGKTMKKMFVLFCMLFSCAFSLAAVNINA
ASQQELEALPGIGPAKAKAIAEYRAQNGAFKSVDDLTKVKGIGPAVLAKLKDQASVGAPAPKAPAKPVLPADKK
MLYPEKMSGMAGRHPYGVRSGLRRNGLKLWDIHFRMTRFIVARCGLLFATLKGKTMKKMFVLFCMLFSCAFSLAAVNINA
ASQQELEALPGIGPAKAKAIAEYRAQNGAFKSVDDLTKVKGIGPAVLAKLKDQASVGAPAPKAPAKPVLPADKK
Nucleotide
Download Length: 465 bp
>NTDB_id=189767 A6L32_RS03485 WP_011798742.1 669735..670199(-) (comE) [Neisseria meningitidis strain M22718]
TTGCTTTACCCGGAAAAAATGTCGGGGATGGCGGGACGGCATCCGTACGGCGTCCGGTCGGGTTTGCGGAGGAACGGCTT
GAAACTTTGGGATATTCATTTTAGAATGACTCGTTTTATCGTCGCAAGATGCGGTTTATTGTTTGCAACCCTTAAAGGAA
AAACCATGAAGAAAATGTTCGTGCTGTTCTGTATGCTGTTCTCCTGCGCCTTCTCCCTTGCGGCGGTAAACATCAATGCG
GCTTCGCAGCAGGAGTTGGAGGCGCTGCCGGGCATAGGCCCTGCGAAGGCGAAGGCCATTGCGGAATACCGTGCGCAAAA
CGGTGCGTTCAAGTCTGTGGACGATTTGACCAAGGTAAAGGGCATCGGCCCTGCGGTGCTGGCGAAGCTGAAGGATCAGG
CTTCTGTCGGCGCGCCCGCACCAAAAGCCCCAGCCAAACCGGTGCTGCCCGCGGATAAAAAATAA
TTGCTTTACCCGGAAAAAATGTCGGGGATGGCGGGACGGCATCCGTACGGCGTCCGGTCGGGTTTGCGGAGGAACGGCTT
GAAACTTTGGGATATTCATTTTAGAATGACTCGTTTTATCGTCGCAAGATGCGGTTTATTGTTTGCAACCCTTAAAGGAA
AAACCATGAAGAAAATGTTCGTGCTGTTCTGTATGCTGTTCTCCTGCGCCTTCTCCCTTGCGGCGGTAAACATCAATGCG
GCTTCGCAGCAGGAGTTGGAGGCGCTGCCGGGCATAGGCCCTGCGAAGGCGAAGGCCATTGCGGAATACCGTGCGCAAAA
CGGTGCGTTCAAGTCTGTGGACGATTTGACCAAGGTAAAGGGCATCGGCCCTGCGGTGCTGGCGAAGCTGAAGGATCAGG
CTTCTGTCGGCGCGCCCGCACCAAAAGCCCCAGCCAAACCGGTGCTGCCCGCGGATAAAAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comE | Neisseria gonorrhoeae MS11 |
93.443 |
79.221 |
0.74 |
| comE | Neisseria gonorrhoeae MS11 |
93.443 |
79.221 |
0.74 |
| comE | Neisseria gonorrhoeae MS11 |
93.443 |
79.221 |
0.74 |
| comE | Neisseria gonorrhoeae MS11 |
93.443 |
79.221 |
0.74 |