Detailed information NTG0185535

Bioinformatically predicted

Overview

• Name: letS
• Type: Regulator
• Locus tag: A9P84_RS09510
• Genome accession: NZ_CP016030
• Coordinates: 2117526..2120258 (+)
• Length: 910 a.a.
• NCBI ID: WP_011214165.1
• Uniprot ID: A0A3A6U6Z5
• Organism: Legionella pneumophila strain OLDA
• Function: regulate competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2112526..2125258

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A9P84_RS09490 (A9P84_09485)	gstA	2112668..2113273 (-)	606	WP_011214161.1	glutathione transferase GstA	-
A9P84_RS09495 (A9P84_09490)	-	2113470..2114465 (-)	996	WP_011214162.1	hypothetical protein	-
A9P84_RS09500 (A9P84_09495)	-	2114506..2115768 (-)	1263	WP_011214163.1	serine hydrolase domain-containing protein	-
A9P84_RS09505 (A9P84_09500)	gltX	2116015..2117427 (-)	1413	WP_011214164.1	glutamate--tRNA ligase	-
A9P84_RS09510 (A9P84_09505)	letS	2117526..2120258 (+)	2733	WP_011214165.1	two-component system sensor histidine kinase LetS	Regulator
A9P84_RS09515 (A9P84_09510)	-	2120356..2121600 (+)	1245	WP_011214166.1	6-phosphofructokinase	-
A9P84_RS09520 (A9P84_09515)	pilA2	2121597..2122010 (-)	414	WP_011214167.1	pilin	Machinery gene
A9P84_RS09525 (A9P84_09520)	pilA2	2122204..2122614 (-)	411	WP_011214168.1	pilin	Machinery gene
A9P84_RS09530 (A9P84_09525)	-	2122917..2123234 (+)	318	WP_011214169.1	BolA family protein	-
A9P84_RS09535 (A9P84_09530)	-	2123309..2124730 (+)	1422	WP_011214170.1	APC family permease	-

Sequence

Protein

• Length: 910 a.a.
• Molecular weight: 102958.49 Da
• Isoelectric Point: 7.6623

>NTDB_id=185535 A9P84_RS09510 WP_011214165.1 2117526..2120258(+) (letS) [Legionella pneumophila strain OLDA]
MLKSIGIKYQLRITTLIPAFLVALLFAFFYNGLFGKDLKQHMSRLGEAYIRQLLPAAQYAMLRNDYRTLQGLINASTINP
EVKALAFYNADGRLIAYRGGKHSIHKPFNPPDYTGDYIESKQINPFTINFIAPITIPKFNLYSSTEFKELSTPKIFQADD
ILGWLSIDIDTQSLLIKRYQMLIVTIFITLFGLLMGLTIHYFLSKRIYMPIARLRRSMKQILSNEFETEIRVSSPGELGI
IEKGCAHLQRQYLNTVRDLNHHIEIATADLQQSLELLEEKNIELSLEKKKTEEKSRQKSEFIANMSHEIRTPMNGVIGFT
NVLLESKLDPLQLDYVKTIKSSAQDLLSIINDILDFSKIDAGKLNLDCIPLDIRGCIDEVLSLASPNAHKKGIDLIPITD
INVPKMVLGDPLRIKQIISNLVTNAVKFTDHGYVLIRTKIEQETDKDYTLLFAITDTGIGISPEDQTKLFTAFNQADTSI
TRRYGGSGLGLVICKKLCEEMHGRISLTSEINKGSTFSARIKVEKLVAYEIEKNQTHRFAHLKIICFDDNPLHLEAIGNG
LGFWGIEAIRVDSFNKLSRILTKHKDCKIAFINVNQGCERQAAELIAKHKQIPFVLISKWPINDFAALGARGFLYKPISI
QKLQDLIESIANENQTEKNTNQELDTLREQLRFLHPEILIAEDNPVNKMLLTSLLNNNANITTVDDGEMAVTACEDKKFD
MILLDLHMPKLNGLEAAKMIRQKSLMNKHSPIVLITASSSDLSSIDMKKSGVDFCFQKPIDEKQLLIQILRIVDKTKHAA
IDWQLCVQKVSGNQALAEEFLAKFIEELYKNREEFIELMHQKNVKGLADLAHKLHGACCFCGVPILQKRVAQLEKLARRT
ANADNLTGAFTDLIQSIDAVISEYENQYSQ

Nucleotide

• Length: 2733 bp

>NTDB_id=185535 A9P84_RS09510 WP_011214165.1 2117526..2120258(+) (letS) [Legionella pneumophila strain OLDA]
ATGTTGAAAAGTATTGGTATTAAATATCAGCTAAGAATCACTACTCTTATTCCTGCCTTTTTAGTCGCCTTGCTTTTTGC
TTTTTTTTATAACGGCCTATTTGGTAAAGATTTAAAGCAGCATATGTCCAGACTGGGTGAAGCCTATATTAGGCAATTAC
TTCCAGCAGCCCAGTATGCCATGCTTCGCAATGATTACCGTACATTGCAGGGTTTAATCAATGCCTCAACCATTAACCCG
GAGGTAAAAGCTTTGGCATTTTATAATGCTGATGGTCGATTAATTGCTTATCGTGGTGGCAAGCATTCTATTCATAAACC
ATTCAACCCACCTGACTATACAGGTGACTACATTGAAAGTAAGCAAATTAACCCATTCACCATTAATTTCATAGCACCGA
TTACTATCCCAAAGTTCAATTTGTACTCCAGCACAGAGTTCAAAGAGCTTTCTACGCCTAAAATATTCCAGGCTGACGAT
ATATTAGGCTGGTTATCTATTGACATTGATACACAATCACTACTTATAAAACGCTATCAAATGCTCATCGTTACCATTTT
TATTACCCTATTCGGTTTACTGATGGGTTTAACAATTCATTACTTCTTGTCTAAACGAATTTACATGCCTATTGCTCGAT
TGCGTCGAAGTATGAAGCAAATTTTAAGTAATGAATTTGAAACTGAAATTCGTGTTTCAAGTCCAGGAGAATTAGGAATA
ATTGAAAAAGGTTGCGCTCATTTACAACGACAATATTTAAATACAGTTCGTGATTTGAATCACCACATTGAAATCGCCAC
AGCAGATCTGCAACAAAGTCTAGAACTTCTGGAAGAAAAAAACATTGAGCTATCACTGGAAAAGAAAAAAACTGAAGAAA
AAAGTCGACAAAAATCAGAATTTATTGCCAACATGAGCCATGAAATTCGCACCCCAATGAATGGCGTGATTGGTTTTACA
AACGTTTTATTGGAAAGCAAGCTGGACCCTTTACAACTGGACTACGTTAAAACGATCAAATCATCAGCGCAGGATTTGTT
AAGTATCATCAATGATATTCTGGATTTTTCTAAAATTGATGCGGGCAAATTAAATCTTGATTGCATCCCGCTAGACATAA
GAGGTTGCATTGATGAGGTTTTATCCCTGGCAAGCCCCAATGCGCACAAAAAAGGAATCGATTTAATCCCGATTACAGAC
ATCAATGTGCCCAAAATGGTATTGGGTGACCCTTTAAGAATCAAACAAATCATCAGTAATCTGGTGACCAATGCAGTAAA
ATTTACAGATCATGGATACGTTCTTATACGCACTAAAATCGAGCAAGAAACAGATAAAGATTATACCTTGCTATTTGCCA
TTACGGATACGGGAATAGGTATTTCACCAGAGGATCAAACGAAACTGTTTACTGCCTTCAATCAGGCAGACACCAGCATC
ACACGCCGTTACGGTGGCTCGGGATTAGGCTTGGTTATATGTAAAAAACTATGTGAAGAAATGCATGGACGTATTAGTCT
AACCAGTGAAATCAACAAAGGCTCTACTTTTAGCGCACGCATTAAAGTTGAAAAACTTGTTGCTTATGAGATTGAAAAAA
ATCAAACTCATCGTTTCGCCCATTTAAAAATCATTTGCTTTGATGACAATCCCCTCCATTTGGAAGCAATAGGTAATGGC
TTGGGATTTTGGGGTATAGAGGCTATACGCGTTGACTCATTTAATAAACTTTCCCGAATATTGACAAAACATAAAGATTG
CAAAATTGCCTTTATTAACGTCAATCAAGGATGTGAGCGACAAGCTGCTGAACTCATTGCCAAACATAAGCAAATCCCTT
TCGTGTTAATTTCCAAATGGCCTATTAATGATTTTGCAGCGCTTGGTGCCAGGGGTTTTCTTTACAAACCTATTAGTATC
CAAAAGCTTCAGGATCTGATTGAATCGATAGCCAATGAAAACCAAACCGAGAAAAATACGAACCAGGAACTGGATACTTT
ACGCGAACAGCTTCGTTTTCTTCATCCAGAGATACTGATTGCAGAAGACAACCCTGTCAATAAAATGCTATTAACATCCC
TATTAAACAATAATGCCAATATAACAACGGTTGACGATGGCGAAATGGCCGTTACTGCTTGTGAGGATAAAAAATTTGAC
ATGATTTTACTTGATCTGCATATGCCAAAACTTAATGGTTTGGAAGCAGCCAAAATGATACGTCAAAAATCCCTAATGAA
TAAACACTCCCCTATCGTTCTCATTACCGCCAGTAGCAGTGATCTGAGTTCCATCGATATGAAAAAATCCGGAGTTGATT
TTTGTTTTCAAAAACCTATAGATGAAAAGCAATTGTTAATCCAAATTCTTCGCATCGTTGATAAAACCAAACATGCTGCC
ATCGATTGGCAATTATGCGTTCAGAAAGTTTCAGGTAATCAAGCGCTTGCTGAAGAGTTCCTCGCCAAATTCATAGAAGA
ATTATATAAGAATCGTGAAGAGTTTATTGAGTTAATGCATCAAAAAAACGTAAAGGGCCTGGCTGATTTGGCTCATAAAT
TACATGGCGCCTGTTGTTTTTGTGGTGTACCTATTTTACAAAAGAGAGTAGCTCAATTAGAGAAGCTTGCAAGACGAACA
GCTAATGCTGATAATTTAACCGGAGCCTTTACCGATTTAATACAAAGTATTGATGCAGTGATTAGTGAATATGAAAATCA
GTATTCACAATAA

Domains

Predicted by InterproScan.

• Hpt domain (Hpt) (819-895)

• Response regulator receiver domain (Response_reg) (678-787)

• Single cache domain 4 (sCache_4) (36-180)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (409-524)

• His Kinase A (phospho-acceptor) domain (HisKA) (298-362)

3D structure

• AlphaFold DB: A0A3A6U6Z5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
letS	Legionella pneumophila strain ERS1305867	99.67	100	0.997