Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EC767_RS22380 Genome accession   NZ_CP020107
Coordinates   4302598..4303257 (+) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain 13E0767     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4297598..4308257
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EC767_RS22355 (EC767_22360) plsC 4297745..4298482 (-) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -
  EC767_RS22360 (EC767_22365) parC 4298715..4300973 (-) 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
  EC767_RS22370 (EC767_22375) ygiV 4301519..4302001 (-) 483 WP_000183481.1 GyrI-like domain-containing protein -
  EC767_RS22375 (EC767_22380) ygiW 4302054..4302446 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  EC767_RS22380 (EC767_22385) ciaR 4302598..4303257 (+) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  EC767_RS22385 (EC767_22390) qseC 4303254..4304603 (+) 1350 WP_024243350.1 quorum sensing histidine kinase QseC -
  EC767_RS22390 (EC767_22395) ygiZ 4304649..4304981 (-) 333 WP_024243349.1 DUF2645 family protein -
  EC767_RS22395 (EC767_22400) mdaB 4305339..4305920 (+) 582 WP_080029854.1 NADPH:quinone oxidoreductase MdaB -
  EC767_RS22400 (EC767_22405) ygiN 4305951..4306265 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  EC767_RS22405 (EC767_22410) parE 4306313..4308205 (-) 1893 WP_040092393.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=185078 EC767_RS22380 WP_001221502.1 4302598..4303257(+) (ciaR) [Escherichia coli strain 13E0767]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=185078 EC767_RS22380 WP_001221502.1 4302598..4303257(+) (ciaR) [Escherichia coli strain 13E0767]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACTGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCACTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAACTGCGCCACGGGAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365

Multiple sequence alignment