Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   BE930_RS22955 Genome accession   NZ_CP019029
Coordinates   4007322..4007981 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain Ecol_881     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4002322..4012981
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BE930_RS22925 (BE930_23380) - 4002438..4003385 (+) 948 WP_001305106.1 iron-siderophore ABC transporter substrate-binding protein -
  BE930_RS22930 (BE930_23385) - 4003382..4004269 (+) 888 WP_000614960.1 MurR/RpiR family transcriptional regulator -
  BE930_RS22935 (BE930_23390) ygiN 4004314..4004628 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  BE930_RS22940 (BE930_23395) mdaB 4004659..4005240 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  BE930_RS22945 (BE930_23400) ygiZ 4005598..4005930 (+) 333 WP_022646136.1 DUF2645 family protein -
  BE930_RS22950 (BE930_23405) qseC 4005976..4007325 (-) 1350 WP_022646135.1 quorum sensing histidine kinase QseC -
  BE930_RS22955 (BE930_23410) ciaR 4007322..4007981 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  BE930_RS22960 (BE930_23415) ygiW 4008133..4008525 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  BE930_RS22965 (BE930_23420) ygiV 4008578..4009060 (+) 483 WP_000183492.1 GyrI-like domain-containing protein -
  BE930_RS22970 (BE930_23425) ygiS 4009169..4010776 (+) 1608 WP_022646134.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=178316 BE930_RS22955 WP_001221493.1 4007322..4007981(-) (ciaR) [Escherichia coli strain Ecol_881]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=178316 BE930_RS22955 WP_001221493.1 4007322..4007981(-) (ciaR) [Escherichia coli strain Ecol_881]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365