Detailed information NTG0176813

Bioinformatically predicted

Overview

• Name: pilR
• Type: Regulator
• Locus tag: A4W92_RS11170
• Genome accession: NZ_CP015117
• Coordinates: 2376447..2377784 (+)
• Length: 445 a.a.
• NCBI ID: WP_003094694.1
• Uniprot ID: A0A0H2ZG94
• Organism: Pseudomonas aeruginosa strain ATCC 27853
• Function: regulate pilin expression (predicted from homology) Competence regulation

Genomic Context

Location: 2371447..2382784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A4W92_RS11145 (A4W92_11145)	pgeF	2371590..2372318 (-)	729	WP_003102588.1	peptidoglycan editing factor PgeF	-
A4W92_RS11150 (A4W92_11150)	rluD	2372315..2373277 (-)	963	WP_003094686.1	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	-
A4W92_RS11155 (A4W92_11155)	-	2373423..2374448 (+)	1026	WP_003102590.1	outer membrane protein assembly factor BamD	-
A4W92_RS11160 (A4W92_11160)	-	2374605..2374850 (+)	246	WP_003102591.1	PP0621 family protein	-
A4W92_RS11165 (A4W92_11165)	pilS	2374840..2376432 (+)	1593	WP_003123394.1	two-component system sensor histidine kinase PilS	Regulator
A4W92_RS11170 (A4W92_11170)	pilR	2376447..2377784 (+)	1338	WP_003094694.1	two-component system response regulator PilR	Regulator
A4W92_RS11175 (A4W92_11175)	thiO	2377830..2378924 (-)	1095	WP_020750388.1	glycine oxidase ThiO	-
A4W92_RS11180 (A4W92_11180)	-	2379059..2379568 (+)	510	WP_003102595.1	GspH/FimT family pseudopilin	-
A4W92_RS11185 (A4W92_11185)	-	2379674..2380180 (+)	507	WP_003102598.1	GspH/FimT family pseudopilin	-
A4W92_RS11190 (A4W92_11190)	pilV	2380171..2380728 (+)	558	WP_003119423.1	type 4a pilus minor pilin PilV	Machinery gene
A4W92_RS11195 (A4W92_11195)	pilW	2380725..2381549 (+)	825	WP_003119422.1	type 4a pilus minor pilin PilW	-
A4W92_RS11200 (A4W92_11200)	pilX	2381546..2382133 (+)	588	WP_003112826.1	type 4a pilus minor pilin PilX	-

Sequence

Protein

• Length: 445 a.a.
• Molecular weight: 49737.06 Da
• Isoelectric Point: 5.8654

>NTDB_id=176813 A4W92_RS11170 WP_003094694.1 2376447..2377784(+) (pilR) [Pseudomonas aeruginosa strain ATCC 27853]
MSRQKALIVDDEPDIRELLEITLGRMKLDTRSARNVKEARELLAREPFDLCLTDMRLPDGSGLDLVQYIQQRHPQTPVAM
ITAYGSLDTAIQALKAGAFDFLTKPVDLGRLRELVATALRLRNPEAEEAPVDNRLLGESPPMRALRNQIGKLARSQAPVY
ISGESGSGKELVARLIHEQGPRIERPFVPVNCGAIPSELMESEFFGHKKGSFTGAIEDKQGLFQAASGGTLFLDEVADLP
MAMQVKLLRAIQEKAVRAVGGQQEVAVDVRILCATHKDLAAEVGAGRFRQDLYYRLNVIELRVPPLRERREDIPLLAERI
LKRLAGDTGLPAARLTGDAQEKLKNYRFPGNVRELENMLERAYTLCEDDQIQPHDLRLADAPGASQEGAASLSEIDNLED
YLEDIERKLIMQALEETRWNRTAAAQRLGLTFRSMRYRLKKLGID

Nucleotide

• Length: 1338 bp

>NTDB_id=176813 A4W92_RS11170 WP_003094694.1 2376447..2377784(+) (pilR) [Pseudomonas aeruginosa strain ATCC 27853]
ATGAGCCGACAAAAAGCCCTGATCGTCGACGATGAACCGGATATCCGCGAACTGCTGGAAATCACTCTCGGCCGCATGAA
GCTGGACACCCGCAGCGCCCGCAACGTCAAGGAAGCCCGCGAGTTGCTGGCCCGCGAGCCGTTCGACCTGTGCCTCACCG
ACATGCGCCTGCCGGACGGCAGCGGCCTCGATCTGGTCCAGTACATCCAGCAGCGCCATCCACAAACCCCGGTGGCCATG
ATCACCGCGTACGGCAGCCTGGACACCGCGATCCAGGCGCTCAAGGCCGGTGCCTTCGACTTCCTCACCAAACCGGTCGA
CCTCGGTCGCTTGCGGGAGCTGGTGGCAACCGCCCTGCGCTTGCGCAACCCGGAAGCCGAGGAAGCGCCGGTGGACAACC
GCCTGCTCGGCGAGTCGCCGCCGATGCGCGCCCTGCGCAACCAGATCGGCAAGCTGGCGCGCAGCCAGGCGCCGGTCTAC
ATCAGTGGCGAGTCCGGTAGCGGCAAGGAGCTGGTGGCGCGCCTGATCCACGAGCAGGGGCCACGTATCGAGCGGCCGTT
CGTGCCGGTGAACTGCGGCGCGATTCCCTCCGAACTGATGGAAAGCGAGTTCTTCGGCCACAAGAAAGGCAGCTTCACTG
GCGCTATCGAAGACAAGCAGGGCCTGTTCCAGGCCGCCAGCGGCGGCACCCTGTTCCTCGACGAAGTCGCCGACCTGCCG
ATGGCCATGCAGGTCAAACTGCTCCGGGCGATCCAGGAAAAGGCCGTGCGCGCGGTCGGCGGCCAGCAGGAGGTCGCCGT
CGACGTGCGCATCCTCTGCGCCACCCACAAGGACCTCGCCGCCGAAGTCGGCGCCGGGCGCTTCCGCCAGGACCTCTACT
ACCGCCTCAACGTCATCGAGCTGCGCGTACCGCCGCTGCGCGAACGCCGCGAGGACATCCCGCTGCTCGCCGAACGCATC
CTCAAGCGCCTGGCCGGCGACACCGGCCTGCCGGCCGCCAGGCTGACCGGCGACGCACAGGAGAAGCTGAAGAACTACCG
CTTCCCGGGCAACGTCCGCGAGCTGGAAAACATGCTGGAGCGCGCCTACACCCTGTGCGAAGACGACCAGATCCAGCCTC
ACGACCTGCGCCTGGCCGATGCGCCGGGTGCCAGCCAGGAAGGCGCCGCGAGCCTGAGCGAAATAGACAACCTCGAGGAC
TACCTGGAAGACATCGAGCGCAAGCTGATCATGCAGGCGCTCGAGGAGACCCGCTGGAACCGCACCGCCGCGGCTCAGCG
TCTGGGCCTGACGTTCCGCTCGATGCGCTACCGCCTGAAAAAGCTGGGCATCGACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (7-115)

• Sigma-54 interaction domain (Sigma54_activat) (135-301)

• Bacterial regulatory protein, Fis family (HTH_8) (402-442)

3D structure

• AlphaFold DB: A0A0H2ZG94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilR	Pseudomonas aeruginosa PAK	100	100	1
pilR	Acinetobacter baumannii strain A118	51.198	100	0.528
luxO	Vibrio cholerae strain A1552	38.17	100	0.384