Detailed information NTG0173339

Bioinformatically predicted

Overview

• Name: comE/comE1
• Type: Regulator
• Locus tag: A0O21_RS02105
• Genome accession: NZ_CP014699
• Coordinates: 443968..444699 (-)
• Length: 243 a.a.
• NCBI ID: WP_067060564.1
• Uniprot ID: A0A172Q5Z8
• Organism: Streptococcus pantholopis strain TA 26
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 438968..449699

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A0O21_RS02090 (A0O21_02095)	-	439900..442263 (+)	2364	WP_067060559.1	DNA translocase FtsK	-
A0O21_RS02095 (A0O21_02100)	-	442499..442636 (+)	138	WP_067060561.1	bacteriocin	-
A0O21_RS02100 (A0O21_02105)	-	442653..443960 (-)	1308	WP_067065033.1	sensor histidine kinase	-
A0O21_RS02105 (A0O21_02110)	comE/comE1	443968..444699 (-)	732	WP_067060564.1	response regulator transcription factor	Regulator
A0O21_RS02110 (A0O21_02115)	-	444816..445778 (-)	963	WP_067060566.1	thioredoxin family protein	-
A0O21_RS02115 (A0O21_02120)	-	446111..446413 (-)	303	WP_067060568.1	bacteriocin immunity protein	-
A0O21_RS02120 (A0O21_02125)	-	446428..446607 (-)	180	WP_099092232.1	garvicin Q family class II bacteriocin	-
A0O21_RS02125 (A0O21_02130)	-	446879..447175 (-)	297	WP_067060570.1	bacteriocin immunity protein	-
A0O21_RS02130 (A0O21_02135)	-	447175..447393 (-)	219	WP_067060572.1	leucocin A/sakacin P family class II bacteriocin	-
A0O21_RS02135 (A0O21_02140)	-	447652..448023 (-)	372	WP_067065038.1	hypothetical protein	-
A0O21_RS10580	-	448295..448567 (-)	273	WP_335742808.1	Blp family class II bacteriocin	-
A0O21_RS02140 (A0O21_02145)	-	448697..448879 (-)	183	WP_067060575.1	Blp family class II bacteriocin	-
A0O21_RS02145 (A0O21_02150)	-	448909..449109 (-)	201	WP_067060577.1	Blp family class II bacteriocin	-
A0O21_RS02150 (A0O21_02155)	-	449492..449695 (-)	204	WP_067060579.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28706.90 Da
• Isoelectric Point: 7.1067

>NTDB_id=173339 A0O21_RS02105 WP_067060564.1 443968..444699(-) (comE/comE1) [Streptococcus pantholopis strain TA 26]
MLDIYILEDDIIQQFRMEREIEAIMSKNHWLYQRLETFSSSKDIIAKSSEKGEHQIFFLDLEIKEDKKQGIEVAKAIREK
DATAIIVFITSHSEFMLITYQSLVGAIDFIDKNLNKQDFSERIELCLKEAMKHQSGYFGESYYLFETSKARVRIPYNDIL
YFETSPAAHRVILHTKNDRFEFYATIAEVAKSDKRLFKCHRSFVINVDNVKRFDKQRRSAYFETGDYCLVSRDKVKALLS
EMR

Nucleotide

• Length: 732 bp

>NTDB_id=173339 A0O21_RS02105 WP_067060564.1 443968..444699(-) (comE/comE1) [Streptococcus pantholopis strain TA 26]
ATGTTAGATATTTATATACTTGAGGATGATATCATTCAACAATTTCGTATGGAGCGTGAAATTGAAGCGATTATGTCAAA
AAATCATTGGCTTTATCAAAGATTAGAGACTTTTAGTTCTTCAAAGGATATTATAGCTAAGTCATCTGAAAAAGGGGAAC
ATCAAATTTTCTTTCTTGATTTAGAAATTAAAGAGGATAAAAAGCAAGGGATAGAGGTTGCCAAAGCTATCCGTGAAAAA
GATGCAACAGCCATTATTGTTTTTATCACAAGTCATTCAGAATTTATGCTCATAACTTATCAATCGCTGGTAGGGGCCAT
CGATTTTATCGATAAAAATCTGAATAAGCAGGATTTCAGTGAACGTATAGAACTGTGTTTAAAAGAAGCCATGAAGCACC
AATCTGGTTATTTTGGTGAGAGTTATTATTTATTTGAAACATCAAAAGCACGAGTACGCATACCTTATAATGATATTCTT
TATTTTGAAACATCTCCTGCTGCACATCGTGTTATTTTACATACAAAAAATGACAGGTTTGAATTTTATGCAACCATCGC
AGAAGTGGCTAAATCTGACAAACGTCTCTTCAAATGCCATCGTTCTTTTGTTATCAATGTGGATAATGTCAAAAGATTTG
ATAAACAAAGACGGAGTGCCTACTTTGAAACAGGGGATTACTGTCTAGTTTCCAGAGATAAAGTAAAAGCCCTCTTGAGT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-238)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A172Q5Z8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus equinus JB1	72.84	100	0.728
comE/blpR	Streptococcus mutans UA159	47.28	98.354	0.465
comE/comE2	Streptococcus equinus JB1	43.802	99.588	0.436