Detailed information NTG0169974

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: AXE83_RS00740
• Genome accession: NZ_CP014264
• Coordinates: 131652..133805 (+)
• Length: 717 a.a.
• NCBI ID: WP_060955046.1
• Uniprot ID: A0A0X8JWH7
• Organism: Streptococcus sp. oral taxon 431 strain F0610 (5-114)
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 126652..138805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AXE83_RS00690 (AXE83_00690)	recO	126873..127643 (+)	771	WP_060955038.1	DNA repair protein RecO	-
AXE83_RS00695 (AXE83_00695)	plsX	127640..128632 (+)	993	WP_060955039.1	phosphate acyltransferase PlsX	-
AXE83_RS00700 (AXE83_00700)	-	128638..128874 (+)	237	WP_060955040.1	acyl carrier protein	-
AXE83_RS11485 (AXE83_00705)	-	129335..129478 (+)	144	WP_060955041.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
AXE83_RS11490 (AXE83_00710)	-	129496..129645 (+)	150	WP_060955042.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
AXE83_RS11135	-	129658..129834 (+)	177	WP_190279315.1	hypothetical protein	-
AXE83_RS11140	-	130045..130200 (+)	156	WP_190279316.1	hypothetical protein	-
AXE83_RS11325 (AXE83_00715)	-	130239..130451 (+)	213	WP_060955043.1	hypothetical protein	-
AXE83_RS00720 (AXE83_00720)	-	130532..130720 (+)	189	WP_060955044.1	hypothetical protein	-
AXE83_RS00730 (AXE83_00730)	-	131061..131297 (+)	237	WP_060955045.1	hypothetical protein	-
AXE83_RS11335 (AXE83_00735)	-	131290..131481 (+)	192	WP_060956342.1	hypothetical protein	-
AXE83_RS00740 (AXE83_00740)	comA	131652..133805 (+)	2154	WP_060955046.1	peptide cleavage/export ABC transporter ComA	Regulator
AXE83_RS00745 (AXE83_00745)	comB	133818..135167 (+)	1350	WP_060955047.1	bacteriocin secretion accessory protein	Regulator
AXE83_RS00750 (AXE83_00750)	purC	135336..136043 (+)	708	WP_060955048.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80345.41 Da
• Isoelectric Point: 6.7019

>NTDB_id=169974 AXE83_RS00740 WP_060955046.1 131652..133805(+) (comA) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MKFSKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDV
TFPFVAHVLKEGKLLHYYVVTGQDKNNIHIADPDPSVKLTKISRERFAKEWTGITIFMAPSPSYKPHKEQKNGLLSFIPI
LVKQRGLIVNIVLATLLVTLINIVGSYYLQSIIDTYVPDQMHSTLGIISIGLVIVYVLQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVLIISVVLFSQNSNLFFMSLLALPIYTV
IIFAFMKPFEKMNRETMEANAVLSSSIIEDINGIETIKSLTSESSRYQKIDKEFVDYLKKSFTYSRAESQQKALKKLAQL
LLNVAILWMGALLVMDNKMSLGQLITYNTLLIYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVSDLSLL
EGDMTFKQVHYKYGYGRDVLSDINLTIAQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNRIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGTHMDLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=169974 AXE83_RS00740 WP_060955046.1 131652..133805(+) (comA) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGAAATTTAGTAAACGGCATTATCGTCCTCAGGTAGACCAGATGGACTGCGGTGTGGCTTCATTAGCCATGGTCTTTGG
TTATTATGGTAGTTATTATTCTCTGGCTCACTTGCGAGAGTTGGCCAAGACGACCATGGATGGGACTACGGCTTTAGGTT
TAGTCAAGGTTGCTGAGGAGATAGGTTTTGAGACGCGAGCAATAAAGGCGGACATGACCTTGTTTGATTTGCCGGATGTA
ACTTTTCCTTTTGTGGCTCATGTGCTTAAGGAAGGGAAATTGCTCCATTATTATGTGGTGACTGGCCAGGACAAGAACAA
CATTCATATTGCTGATCCAGATCCTAGTGTTAAGCTGACCAAGATTTCTCGTGAGCGCTTTGCCAAGGAGTGGACAGGAA
TCACTATTTTTATGGCTCCATCTCCGAGTTATAAGCCTCATAAGGAACAAAAAAATGGGCTTCTCTCCTTTATCCCTATA
TTAGTGAAACAGCGTGGCTTGATTGTCAATATCGTTTTGGCGACCCTCTTGGTGACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGACACTTATGTACCAGATCAGATGCACTCGACACTGGGAATTATTTCGATAGGGCTAGTCA
TCGTTTATGTCCTTCAGCAAATCTTATCTTATGCCCAGGAGTATCTTTTACTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCTTATATCAAGCATGTTTTTCATTTACCTATGTCCTTTTTTGCGACACGACGGACAGGGGAAATCGTGTC
TCGTTTCACGGATGCGAATAGTATCATCGATGCACTGGCTTCAACTATTCTGTCAATCTTTTTGGATGTATCTACTGTCT
TGATTATTTCAGTAGTTCTATTTTCGCAGAATAGCAATCTCTTTTTCATGAGTTTACTAGCCCTTCCTATCTACACAGTG
ATTATCTTTGCTTTTATGAAGCCCTTTGAAAAGATGAATCGGGAAACTATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACCATCAAGTCCTTAACTAGCGAAAGTTCACGCTACCAAAAGATTGACAAGGAAT
TTGTAGATTATCTGAAAAAATCTTTTACTTACAGTCGGGCAGAAAGTCAGCAAAAGGCTCTGAAAAAGCTTGCCCAACTC
TTGCTCAATGTTGCCATTCTCTGGATGGGGGCTCTCCTAGTCATGGACAATAAGATGAGTTTGGGCCAGTTGATTACCTA
TAATACCTTGCTTATTTACTTTACAAATCCATTGGAAAATATCATCAATCTGCAAACCAAACTTCAGACAGCGCAGGTAG
CCAATAACCGTCTCAATGAAGTTTATCTGGTTGCATCTGAGTTTGAGGAAAAGAAAACAGTCTCGGATTTGAGCTTGCTA
GAAGGAGATATGACTTTTAAGCAGGTTCACTACAAATATGGCTATGGTCGAGATGTCTTGTCGGACATCAATCTAACCAT
TGCGCAAGGCTCTAAAGTGGCTTTTGTAGGGATTTCAGGATCGGGTAAGACGACCTTGGCTAAGATGATGGTTAATTTTT
ATGATCCTAGTCAGGGGGAGATTAGTCTGGGTGGTGTCAATCTTAATCGGATTGATAAAAAGGCTCTGCGCCAGTATATC
AACTACCTGCCTCAGCAGCCCTACGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTCGGAGCTAAGGAGGGGACGAC
CCAGGAGGATATCTTGAGAGCAGTGGAGTTGGCAGAGATTCGGGAGGATATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGAGCGGGCATTTCAGGTGGGCAACGTCAGAGGATCGCTTTGGCGCGTGCTCTCTTGACCGATGCG
CCTGTCTTGATCTTGGATGAGGCGACTAGCAGTCTAGATATTTTGACCGAGAAGCGAATTGTCGATAATCTCATGGCTTT
GGATAAGACCTTGATTTTCATCGCCCACCGTTTAACCATTGCTGAGCGGACAGAGAAGGTTGTCGTTTTGGATCAAGGCA
AGATTGTCGAAGAGGGTACACATATGGATTTACTGGCTCAGGGTGGTTTTTATGCCCACTTGGTGAATAGTTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

3D structure

• AlphaFold DB: A0A0X8JWH7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae Rx1	94.7	100	0.947
comA	Streptococcus pneumoniae D39	94.7	100	0.947
comA	Streptococcus pneumoniae R6	94.7	100	0.947
comA	Streptococcus mitis NCTC 12261	94.7	100	0.947
comA	Streptococcus mitis SK321	94.421	100	0.944
comA	Streptococcus pneumoniae TIGR4	94.282	100	0.943
comA	Streptococcus gordonii str. Challis substr. CH1	81.172	100	0.812
comA/nlmT	Streptococcus mutans UA159	66.109	100	0.661