Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE1   Type   Regulator
Locus tag   AU077_RS00695 Genome accession   NZ_CP013688
Coordinates   136073..136804 (+) Length   243 a.a.
NCBI ID   WP_058621372.1    Uniprot ID   -
Organism   Streptococcus gallolyticus strain ICDDRB-NRC-S1     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 123729..136804 136073..136804 within 0
IScluster/Tn 131476..135495 136073..136804 flank 578


Gene organization within MGE regions


Location: 123729..136804
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AU077_RS00585 (AU077_00585) - 123729..123950 (+) 222 WP_058621357.1 leucocin A/sakacin P family class II bacteriocin -
  AU077_RS00590 (AU077_00590) - 123950..124246 (+) 297 WP_058621358.1 bacteriocin immunity protein -
  AU077_RS00595 (AU077_00595) - 124415..124648 (+) 234 WP_058621359.1 Blp family class II bacteriocin -
  AU077_RS00600 (AU077_00600) - 124838..125080 (+) 243 WP_058621360.1 garvicin Q family class II bacteriocin -
  AU077_RS00605 (AU077_00605) - 125095..125403 (+) 309 WP_018364976.1 bacteriocin immunity protein -
  AU077_RS00610 (AU077_00610) - 126054..126254 (+) 201 WP_058621361.1 bacteriocin class II family protein -
  AU077_RS00615 (AU077_00615) - 126280..126462 (+) 183 WP_006531883.1 Blp family class II bacteriocin -
  AU077_RS00620 (AU077_00620) - 127081..127311 (+) 231 WP_058621362.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  AU077_RS00625 (AU077_00625) - 127401..127712 (+) 312 WP_058621363.1 hypothetical protein -
  AU077_RS00630 (AU077_00630) - 127880..128518 (+) 639 WP_058621364.1 CPBP family intramembrane glutamic endopeptidase -
  AU077_RS00635 (AU077_00635) - 128677..128976 (+) 300 WP_082306717.1 Blp family class II bacteriocin -
  AU077_RS00640 (AU077_00640) - 128996..129184 (+) 189 WP_006531876.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  AU077_RS00645 (AU077_00645) - 129933..130151 (+) 219 WP_058621365.1 Blp family class II bacteriocin -
  AU077_RS00650 (AU077_00650) - 130151..130447 (+) 297 WP_003066579.1 bacteriocin immunity protein -
  AU077_RS00655 (AU077_00655) - 130619..131338 (+) 720 WP_230937574.1 thioredoxin family protein -
  AU077_RS10505 - 131476..133046 (+) 1571 WP_099412448.1 IS3 family transposase -
  AU077_RS00675 (AU077_00675) - 133642..133842 (+) 201 WP_058621369.1 hypothetical protein -
  AU077_RS00690 (AU077_00690) - 135730..136056 (+) 327 WP_058621371.1 LytTR family DNA-binding domain-containing protein -
  AU077_RS00695 (AU077_00695) comE/comE1 136073..136804 (+) 732 WP_058621372.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 243 a.a.        Molecular weight: 28480.66 Da        Isoelectric Point: 5.4370

>NTDB_id=164031 AU077_RS00695 WP_058621372.1 136073..136804(+) (comE/comE1) [Streptococcus gallolyticus strain ICDDRB-NRC-S1]
MLDIYVLEDNIIQQFRMEREIATIMAKNNWDYQRIEMFCSANEIIAKATEKGEHQIFFLDLEIRDDEKQGIDVAKAIREK
DATAIIVFVTTHSEFMLLTYQALVGAIDFIDKNLNDQAFSERIELCLKEAMKHQNDNFGENSFLFETPKARVRVLYSDIL
YFETSPAVHRVILHTKNERVEFYATIAEIAKSDKRLFKCHRSFIINVDNVVRFDRATRSVYFETGDTCLVSRDKIKPLLN
EMR

Nucleotide


Download         Length: 732 bp        

>NTDB_id=164031 AU077_RS00695 WP_058621372.1 136073..136804(+) (comE/comE1) [Streptococcus gallolyticus strain ICDDRB-NRC-S1]
ATGTTAGATATTTATGTACTAGAGGATAATATCATACAGCAATTTCGTATGGAACGCGAGATTGCGACCATTATGGCAAA
AAATAATTGGGACTATCAGAGAATAGAGATGTTTTGTTCCGCAAATGAGATTATAGCTAAGGCAACTGAAAAAGGAGAGC
ATCAAATTTTCTTTCTTGATTTAGAAATCAGAGACGACGAAAAACAAGGAATTGATGTCGCTAAAGCTATTCGTGAAAAA
GATGCAACAGCTATCATTGTTTTTGTAACAACTCATTCAGAATTTATGCTGCTGACCTACCAAGCGTTAGTAGGGGCAAT
TGATTTTATTGATAAAAACCTAAATGACCAAGCATTTAGTGAACGCATAGAGTTGTGCCTAAAGGAAGCCATGAAACATC
AAAATGATAATTTCGGCGAAAACTCCTTTTTGTTTGAAACTCCTAAAGCACGTGTGCGCGTTCTATATAGTGATATTCTT
TATTTCGAAACATCTCCTGCCGTGCACCGCGTGATTTTGCATACGAAAAATGAAAGAGTGGAATTTTATGCGACGATTGC
AGAGATTGCTAAATCAGACAAACGTCTTTTCAAGTGTCACCGTTCTTTTATCATTAATGTGGATAATGTGGTTAGATTTG
ATAGAGCGACACGAAGTGTTTATTTCGAAACTGGAGACACTTGCCTAGTTTCGAGGGATAAAATAAAACCTCTATTAAAT
GAGATGAGGTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(11-123)

LytTr DNA-binding domain (LytTR)

(152-238)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE1 Streptococcus equinus JB1

72.016

100

0.72
  comE/blpR Streptococcus mutans UA159

48.954

98.354

0.481
  comE/comE2 Streptococcus equinus JB1

46.281

99.588

0.461

Multiple sequence alignment