Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   APQ13_RS02670 Genome accession   NZ_CP013237
Coordinates   551035..552330 (+) Length   431 a.a.
NCBI ID   WP_061046376.1    Uniprot ID   -
Organism   Streptococcus mutans strain NG8 isolate Dental Plaque     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 546035..557330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  APQ13_RS02650 (APQ13_02645) phoU 546413..547066 (+) 654 WP_002262211.1 phosphate signaling complex protein PhoU -
  APQ13_RS02655 (APQ13_02650) - 547107..549656 (+) 2550 WP_002289306.1 M1 family metallopeptidase -
  APQ13_RS02660 (APQ13_02655) ciaX 550057..550320 (+) 264 WP_002262213.1 three-component system regulator CiaX -
  APQ13_RS02665 (APQ13_02660) ciaR 550371..551045 (+) 675 WP_002262214.1 three-component system response regulator CiaR Regulator
  APQ13_RS02670 (APQ13_02665) ciaH 551035..552330 (+) 1296 WP_061046376.1 three-component system sensor histidine kinase CiaH Regulator
  APQ13_RS02675 (APQ13_02670) rpsT 552419..552673 (-) 255 WP_011074586.1 30S ribosomal protein S20 -
  APQ13_RS02680 (APQ13_02675) coaA 552727..553647 (-) 921 WP_002262217.1 type I pantothenate kinase -
  APQ13_RS02685 (APQ13_02680) - 553743..554339 (+) 597 WP_002270201.1 class I SAM-dependent methyltransferase -
  APQ13_RS02690 (APQ13_02685) - 554448..555725 (+) 1278 WP_002273915.1 pyrimidine-nucleoside phosphorylase -
  APQ13_RS02695 (APQ13_02690) deoC 555744..556406 (+) 663 WP_061046377.1 deoxyribose-phosphate aldolase -
  APQ13_RS02700 (APQ13_02695) - 556312..556782 (+) 471 WP_230311800.1 cytidine deaminase -

Sequence

Protein


Download         Length: 431 a.a.        Molecular weight: 49364.79 Da        Isoelectric Point: 9.8230

>NTDB_id=160968 APQ13_RS02670 WP_061046376.1 551035..552330(+) (ciaH) [Streptococcus mutans strain NG8 isolate Dental Plaque]
MLIKLRKQKQDENISFFSHFFAVFTGIFFVMTVIIIQVMHFGIYSSVDNSLKIATENVNMTLSHNNPITEAENGDASFKV
KSNGQMAANTDTILYDKKHNVINNVNAFSSLYHIRPKLKDIGDIVEQEAKNIYGQTEKYRTVTVKVNNDFYPQIKFATIV
INTTQLEEANTRYVTIIISVMIVFWLISVIASVYLAKWSQKPILENYEKQKSFVENASHELRTPLAVLQNRLESLFRKPE
ATILDSSESIASSLEEVRNMRMLTANLLNLARRDDGIKPEITEIQPRFFDDTFKNYEMIARENGKKLHITNKVNRQIKTD
KTLLKQLMTILFDNAVKYTDNDGEIWLDVKTTDRSLIFSVADNGQGISDEDKKKIFDRFYRVDKARTRQKGGFGLGLSLA
KQITDSLKGSIIVKDKKPQGVMFEARLLANK

Nucleotide


Download         Length: 1296 bp        

>NTDB_id=160968 APQ13_RS02670 WP_061046376.1 551035..552330(+) (ciaH) [Streptococcus mutans strain NG8 isolate Dental Plaque]
ATGCTAATTAAATTAAGAAAACAAAAGCAGGATGAGAATATTTCATTTTTCAGTCATTTCTTTGCTGTTTTTACCGGAAT
ATTCTTTGTTATGACAGTTATTATTATTCAGGTTATGCATTTTGGTATCTATTCTTCAGTTGATAATAGTCTAAAAATAG
CAACTGAGAATGTCAATATGACTCTATCGCATAATAATCCTATTACTGAAGCTGAAAATGGAGATGCCTCTTTTAAAGTA
AAATCAAATGGCCAGATGGCTGCTAATACAGATACTATTCTTTATGATAAAAAGCATAACGTCATCAATAATGTCAATGC
CTTCTCTTCTTTGTATCATATTCGCCCTAAACTAAAAGATATTGGTGATATTGTTGAACAAGAAGCTAAGAATATTTACG
GTCAGACCGAAAAGTATCGGACAGTGACAGTTAAGGTAAATAATGATTTTTACCCACAGATAAAATTTGCAACGATTGTT
ATTAATACAACACAGCTTGAAGAGGCTAATACGCGTTATGTTACGATTATTATCAGTGTGATGATTGTTTTTTGGCTTAT
ATCAGTTATTGCCAGTGTTTATTTAGCGAAGTGGAGTCAAAAACCGATTCTGGAAAATTATGAAAAGCAAAAATCATTTG
TTGAAAATGCTAGTCATGAATTACGTACTCCTTTGGCTGTTTTGCAAAATCGCTTGGAGAGTTTGTTTCGAAAACCAGAG
GCTACTATCTTAGATTCTTCGGAATCTATTGCTTCTAGTTTGGAAGAGGTCAGAAACATGAGAATGCTGACAGCAAATCT
CCTTAATTTAGCCCGTCGGGATGATGGTATCAAACCAGAAATAACAGAAATTCAACCTCGTTTTTTTGATGATACTTTTA
AAAATTATGAGATGATCGCTCGAGAAAATGGGAAAAAATTGCATATTACCAATAAGGTCAACCGTCAAATTAAGACAGAT
AAGACTTTGCTGAAGCAATTAATGACTATTCTTTTTGATAATGCTGTCAAATATACAGATAACGACGGGGAAATTTGGCT
GGACGTCAAGACAACTGATCGCAGTTTAATTTTTTCAGTTGCGGACAATGGTCAAGGTATTTCAGACGAGGATAAGAAGA
AAATTTTTGATCGTTTTTATCGCGTCGATAAAGCCAGAACACGACAAAAGGGTGGGTTCGGACTTGGTTTGTCTTTGGCA
AAACAAATAACAGACAGCTTAAAAGGCAGCATTATTGTTAAAGATAAAAAACCACAAGGAGTAATGTTTGAAGCTCGCCT
GCTTGCTAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(320-427)

His Kinase A (phospho-acceptor) domain (HisKA)

(211-276)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

98.851

100

0.998
  ciaH Streptococcus pneumoniae Rx1

55.632

100

0.561
  ciaH Streptococcus pneumoniae D39

55.632

100

0.561
  ciaH Streptococcus pneumoniae R6

55.632

100

0.561
  ciaH Streptococcus pneumoniae TIGR4

55.632

100

0.561

Multiple sequence alignment