Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   APQ13_RS00975 Genome accession   NZ_CP013237
Coordinates   180339..181691 (+) Length   450 a.a.
NCBI ID   WP_002264821.1    Uniprot ID   A0AAX1K2Z0
Organism   Streptococcus mutans strain NG8 isolate Dental Plaque     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 175339..186691
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  APQ13_RS00945 (APQ13_00945) endA 175359..176240 (+) 882 WP_002266944.1 DNA/RNA non-specific endonuclease Machinery gene
  APQ13_RS00950 (APQ13_00950) - 176308..176958 (-) 651 WP_002262934.1 amino acid ABC transporter permease -
  APQ13_RS00955 (APQ13_00955) - 176973..177677 (-) 705 WP_002262933.1 amino acid ABC transporter permease -
  APQ13_RS00960 (APQ13_00960) - 177695..178507 (-) 813 WP_002262932.1 transporter substrate-binding domain-containing protein -
  APQ13_RS00965 (APQ13_00965) - 178504..179286 (-) 783 WP_002266943.1 amino acid ABC transporter ATP-binding protein -
  APQ13_RS00970 (APQ13_00970) vicR 179639..180346 (+) 708 WP_002262930.1 response regulator YycF Regulator
  APQ13_RS00975 (APQ13_00975) vicK 180339..181691 (+) 1353 WP_002264821.1 cell wall metabolism sensor histidine kinase VicK Regulator
  APQ13_RS00980 (APQ13_00980) vicX 181688..182491 (+) 804 WP_002262928.1 MBL fold metallo-hydrolase Regulator
  APQ13_RS00985 (APQ13_00985) rnc 182598..183293 (+) 696 WP_002266141.1 ribonuclease III -

Sequence

Protein


Download         Length: 450 a.a.        Molecular weight: 51752.41 Da        Isoelectric Point: 4.4951

>NTDB_id=160961 APQ13_RS00975 WP_002264821.1 180339..181691(+) (vicK) [Streptococcus mutans strain NG8 isolate Dental Plaque]
MTNVFESSPLFLRILLAVLIILLFFYFIFLNYREYKNNNQVKQLNAKVRSLITGHYTDKLKVEDNSDLSELVNNVNDLSE
VFRLTHENLAQEKNRLTSILSYMTDGVLATDRRGKITVINDMAQKQLNVTREQALECNILDILDDDSYTYNDLITKTPEI
VLTRRDEYDEFITLRIRFALNRRESGFISGLIAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALTE
SVAPSFIKVSLDETNRMMRMITDLLSLSRIDNQTSHLDVELTNFTAFMNYILDRFDQIQSQQSTNKVYEIIRDYPDKSVW
IEIDTDKMTQVIDNILNNAIKYSPDGGKVTVTMQTTDTQLILSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLG
LAIAKEIVKQHKGFIWANSEEGEGSTFTIVLPYENDNDAIDEWEEDEDES

Nucleotide


Download         Length: 1353 bp        

>NTDB_id=160961 APQ13_RS00975 WP_002264821.1 180339..181691(+) (vicK) [Streptococcus mutans strain NG8 isolate Dental Plaque]
ATGACTAATGTGTTTGAATCAAGTCCCTTATTTTTACGAATTTTATTAGCAGTTTTAATCATTTTACTCTTTTTTTATTT
TATTTTTCTCAATTACAGAGAGTATAAAAATAATAATCAAGTTAAACAGTTAAATGCTAAAGTACGTTCTTTGATTACTG
GCCATTATACTGATAAATTAAAGGTTGAGGATAACTCTGACTTGTCAGAACTAGTGAATAACGTTAATGATTTATCAGAA
GTTTTCCGTTTAACGCATGAAAATTTGGCACAGGAGAAAAACCGTCTGACTAGTATTTTATCTTATATGACAGATGGTGT
TTTGGCAACAGATCGCCGCGGAAAGATTACCGTTATTAACGATATGGCGCAAAAGCAACTGAATGTAACGCGTGAGCAGG
CATTGGAGTGCAATATTCTGGATATTTTGGATGATGATAGTTATACTTACAATGATTTGATTACAAAAACGCCGGAAATT
GTTCTGACGCGGCGTGATGAATATGATGAATTTATCACTTTACGCATTCGTTTTGCCTTAAACCGCCGTGAAAGTGGCTT
TATTTCAGGACTAATTGCTGTCTTGCATGATGCGACCGAACAGGAAAAAGAAGAACGTGAACGCCGTCTCTTTGTTTCTA
ATGTCAGTCATGAACTGCGGACACCATTAACCTCTGTAAAGTCCTATTTAGAAGCTTTGGACGATGGTGCCCTGACAGAA
TCAGTGGCTCCTAGTTTTATCAAGGTATCACTTGATGAGACTAATCGCATGATGCGTATGATTACTGATTTACTTAGCTT
ATCACGTATTGATAATCAGACCAGTCATTTAGATGTTGAATTGACGAATTTTACAGCTTTTATGAATTATATTCTGGATC
GCTTTGATCAAATTCAAAGTCAGCAATCAACTAATAAGGTTTACGAAATTATTAGAGATTATCCTGACAAATCAGTTTGG
ATTGAAATTGATACCGATAAAATGACTCAGGTAATTGATAATATTTTAAATAATGCAATCAAATATTCACCTGATGGCGG
TAAGGTGACTGTAACGATGCAGACAACAGATACACAACTCATCCTTTCTATATCTGACCAAGGCTTGGGTATTCCTAAGA
AGGATCTCCCTCTTATTTTTGACCGTTTTTATCGTGTTGATAAGGCAAGAAGCCGTGCTCAAGGTGGGACTGGTTTAGGA
TTAGCAATCGCCAAAGAAATTGTCAAACAGCATAAAGGCTTTATTTGGGCCAATAGTGAGGAAGGCGAAGGGTCGACCTT
TACCATCGTTTTACCTTATGAAAATGATAATGATGCAATTGATGAATGGGAAGAAGATGAAGACGAATCATGA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)

PAS fold (PAS)

(96-180)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

99.556

100

0.996
  micB Streptococcus pneumoniae Cp1015

67.599

95.333

0.644

Multiple sequence alignment