Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SanJ4211_RS05185 Genome accession   NZ_CP012805
Coordinates   1035379..1036725 (-) Length   448 a.a.
NCBI ID   WP_021001737.1    Uniprot ID   A0AAP6BMN2
Organism   Streptococcus anginosus strain J4211     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1030379..1041725
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SanJ4211_RS05165 (SanJ4211_1014) rpsT 1030790..1031041 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  SanJ4211_RS05170 (SanJ4211_1015) - 1031106..1031615 (+) 510 WP_003024360.1 DNA topology modulation protein -
  SanJ4211_RS05175 (SanJ4211_1016c) - 1031664..1033277 (-) 1614 WP_057489678.1 M20/M25/M40 family metallo-hydrolase -
  SanJ4211_RS05180 (SanJ4211_1017) - 1033454..1034902 (+) 1449 WP_021001736.1 alpha-amylase -
  SanJ4211_RS10275 (SanJ4211_1018c) - 1035099..1035233 (-) 135 WP_256381214.1 hypothetical protein -
  SanJ4211_RS05185 (SanJ4211_1019c) ciaH 1035379..1036725 (-) 1347 WP_021001737.1 sensor histidine kinase Regulator
  SanJ4211_RS05190 (SanJ4211_1020c) ciaR 1036715..1037389 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  SanJ4211_RS05195 (SanJ4211_1021c) - 1037662..1038114 (-) 453 WP_021001738.1 hypothetical protein -
  SanJ4211_RS05200 (SanJ4211_1022c) - 1038439..1039182 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  SanJ4211_RS05205 (SanJ4211_1023) - 1039642..1039890 (+) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  SanJ4211_RS05210 (SanJ4211_1024) - 1039887..1040183 (+) 297 WP_041784012.1 type II toxin-antitoxin system RelE family toxin -
  SanJ4211_RS05215 (SanJ4211_1025c) - 1040314..1041012 (-) 699 WP_021001740.1 hypothetical protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51008.75 Da        Isoelectric Point: 10.1380

>NTDB_id=157710 SanJ4211_RS05185 WP_021001737.1 1035379..1036725(-) (ciaH) [Streptococcus anginosus strain J4211]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=157710 SanJ4211_RS05185 WP_021001737.1 1035379..1036725(-) (ciaH) [Streptococcus anginosus strain J4211]
ATGCTGAATAAACTTAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGACACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT
TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT
GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATTTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTTTAGGGTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551

Multiple sequence alignment