Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   RU53_RS10380 Genome accession   NZ_CP010526
Coordinates   2056803..2057432 (-) Length   209 a.a.
NCBI ID   WP_000153528.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2051803..2062432
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RU53_RS10350 (RU53_2010) - 2052224..2052754 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  RU53_RS10355 (RU53_2011) - 2052844..2054100 (-) 1257 WP_075583716.1 aminopeptidase -
  RU53_RS10360 (RU53_2012) - 2054103..2054303 (-) 201 WP_000180460.1 DUF1128 family protein -
  RU53_RS10365 (RU53_2013) - 2054450..2054914 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  RU53_RS10370 (RU53_2014) - 2054921..2055196 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  RU53_RS10375 (RU53_2015) - 2055474..2056691 (+) 1218 WP_000037078.1 YihY/virulence factor BrkB family protein -
  RU53_RS10380 (RU53_2016) vraR 2056803..2057432 (-) 630 WP_000153528.1 two-component system response regulator VraR Regulator
  RU53_RS10385 (RU53_2017) vraS 2057422..2058465 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  RU53_RS10390 (RU53_2018) liaF 2058462..2059163 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  RU53_RS10395 (RU53_2019) - 2059178..2059564 (-) 387 WP_001110179.1 hypothetical protein -
  RU53_RS10400 (RU53_2020) map 2059781..2060539 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  RU53_RS10410 (RU53_2021) - 2061011..2061997 (+) 987 WP_000999718.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23527.26 Da        Isoelectric Point: 5.3889

>NTDB_id=139091 RU53_RS10380 WP_000153528.1 2056803..2057432(-) (vraR) [Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
ILTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=139091 RU53_RS10380 WP_000153528.1 2056803..2057432(-) (vraR) [Staphylococcus aureus subsp. aureus ST772-MRSA-V strain DAR4145]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATATTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.043

100

0.99
  degU Bacillus subtilis subsp. subtilis str. 168

35.268

100

0.378

Multiple sequence alignment